September 2019, Vol 137, No. 9, Pages 963-1092

In This Issue of JAMA Ophthalmology

Highlights

Abstract Full Text

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JAMA Ophthalmol. 2019;137(9):963. doi:10.1001/jamaophthalmol.2018.4788

Original Investigation

Association of Surgical Setting and Deployment of a New Electronic Health Record With Ophthalmic Operative Times

Shawn Gulati, MD, MPH; Michael V. Boland, MD, PhD

Abstract Full Text

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JAMA Ophthalmol. 2019;137(9):969-974. doi:10.1001/jamaophthalmol.2019.1938

This case series study analyzes electronic health records from 11 064 ophthalmic surgeries to ascertain the associations of electronic health record system replacement and surgical setting with operating times.

Invited Commentary
Making Progress Toward an Electronic Infrastructure for Ophthalmic Care
Michael F. Chiang, MD

Association Between Change in Visual Acuity and Change in Central Subfield Thickness During Treatment of Diabetic Macular Edema in Participants Randomized to Aflibercept, Bevacizumab, or Ranibizumab: A Post Hoc Analysis of the Protocol T Randomized Clinical Trial

Neil M. Bressler, MD; Isoken Odia, OD, MPH; Maureen Maguire, PhD; et al.

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JAMA Ophthalmol. 2019;137(9):977-985. doi:10.1001/jamaophthalmol.2019.1963

This post hoc analysis of a randomized clinical trial compared the changes in visual acuity vs the changes in optical coherence tomographic central subfield thickness measures in evaluation of the outcomes of anti–vascular endothelial growth factor therapy in patients with diabetic macular edema.

Invited Commentary
Seeking Surrogate Markers for Diabetic Macular Edema
Sapna Gangaputra, MD, MPH; Paul Sternberg Jr, MD

Performance of a Deep-Learning Algorithm vs Manual Grading for Detecting Diabetic Retinopathy in India

Varun Gulshan, PhD; Renu P. Rajan, MD; Kasumi Widner, MS; et al.

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JAMA Ophthalmol. 2019;137(9):987-993. doi:10.1001/jamaophthalmol.2019.2004

This study assesses the validity of an automated diabetic retinopathy system compared with manual grading across 2 sites in India.

Invited Commentary
Observations and Lessons Learned From the Artificial Intelligence Studies for Diabetic Retinopathy Screening
Daniel Shu Wei Ting, MD, PhD; Lawrence Carin, PhD; Michael D. Abramoff, MD, PhD

Characterization of Retinopathy Among Patients With Yellow Fever During 2 Outbreaks in Southeastern Brazil

Camilo Brandão-de-Resende, BEng, MD, MSc; Leandro H. M. Cunha, MD; Simone L. Oliveira, MD; et al.

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JAMA Ophthalmol. 2019;137(9):996-1002. doi:10.1001/jamaophthalmol.2019.1956

This cross-sectional single-center study conducted in Southeastern Brazil evaluates clinical findings and biomarkers associated with retinopathy and characterizes retinal changes among patients with confirmed yellow fever during 2 recent outbreaks of the disease.

Audio Author Interview: Retinopathy Characterization Among Patients With Yellow Fever in Southeastern Brazil

Invited Commentary
Insights From 2 Outbreaks in Southeastern Brazil: Yellow Fever Retinopathy
Jessica G. Shantha, MD; Steven Yeh, MD; Nisha Acharya, MD

Genetic Variants Associated With Corneal Biomechanical Properties and Potentially Conferring Susceptibility to Keratoconus in a Genome-Wide Association Study

Anthony P. Khawaja, PhD; Karla E. Rojas Lopez, MSc; Alison J. Hardcastle, PhD; et al.

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JAMA Ophthalmol. 2019;137(9):1005-1012. doi:10.1001/jamaophthalmol.2019.2058

This case-control genome-wide association study identifies genetic variants associated with corneal biomechanical properties and examines whether these variants are associated with keratoconus in adults.

Invited Commentary
Use of Corneal Biomechanical Measures as Endophenotypes for Understanding the Genetics of Keratoconus
Kathryn P. Burdon, PhD, BSc (Hons)

Gender Differences in Case Volume Among Ophthalmology Residents

Dan Gong, MD; Bryan J. Winn, MD; Casey J. Beal, MD; et al.

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JAMA Ophthalmol. 2019;137(9):1015-1020. doi:10.1001/jamaophthalmol.2019.2427

This analysis of case logs from US ophthalmology residency programs assesses differences between male and female ophthalmology residents for cataract surgery and total procedural volume.

Invited Commentary
A Seat at the Operating Room Table in Ophthalmology Surgery
Julia A. Haller, MD; Qiang Zhang, PhD

Monitoring Disease Progression With a Quantitative Severity Scale for Retinopathy of Prematurity Using Deep Learning

Stanford Taylor, MD; James M. Brown, PhD; Kishan Gupta, MD, PhD; et al.

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JAMA Ophthalmol. 2019;137(9):1022-1028. doi:10.1001/jamaophthalmol.2019.2433

This study describes a quantitative retinopathy of prematurity severity score derived using a deep learning algorithm designed to evaluate plus disease and assess its utility for objectively monitoring retinopathy of prematurity progression.

Invited Commentary
Automated Algorithms and Retinopathy of Prematurity Treatment
William V. Good, MD

A Quantitative Severity Scale for Retinopathy of Prematurity Using Deep Learning to Monitor Disease Regression After Treatment

Kishan Gupta, MD, PhD; J. Peter Campbell, MD, MPH; Stanford Taylor, MD; et al.

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JAMA Ophthalmol. 2019;137(9):1029-1036. doi:10.1001/jamaophthalmol.2019.2442

This cohort study uses clinical images collected for the Imaging and Informatics in Retinopathy of Prematurity consortium to assess whether an automated retinopathy of prematurity vascular severity score obtained from a deep learning–based algorithm plus disease classifier can objectively monitor disease progression and regression after treatment among infants with treatment-requiring disease.

Invited Commentary
Automated Algorithms and Retinopathy of Prematurity Treatment
William V. Good, MD

Characteristics of Industry Payments to Ophthalmologists in the Open Payments Database

Dane H. Slentz, MD; Christine C. Nelson, MD; Paul R. Lichter, MD

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JAMA Ophthalmol. 2019;137(9):1038-1044. doi:10.1001/jamaophthalmol.2019.2456

This study examines the characteristics of the reported industry payments made to ophthalmologists in the Open Payments Database from 2013 to 2017.

Association of Preoperative Disclosure of Resident Roles With Informed Consent for Cataract Surgery in a Teaching Program

Alicia M. Corwin, MD; Jonathan N. Rajkumar, MPH; Bruce J. Markovitz, MD; et al.

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JAMA Ophthalmol. 2019;137(9):1045-1051. doi:10.1001/jamaophthalmol.2019.1919

This cohort study investigates the associations of full preoperative disclosure of the resident role with patient consent rates and subjective experience of the consent process in cataract surgery.

Audio Author Interview: Preoperative Disclosure of Resident Roles in Cataract Surgery in Teaching Centers

Invited Commentary
Truth, Transparency, and Teaching
R. Michael Siatkowski, MD

Brief Report

Clinical and Genetic Features of Familial Exudative Vitreoretinopathy With Only-Unilateral Abnormalities in a Chinese Cohort

Tian Tian, MD; Chunli Chen, MD; Xiang Zhang, MD; et al.

Abstract Full Text

JAMA Ophthalmol. 2019;137(9):1054-1058. doi:10.1001/jamaophthalmol.2019.1493

This study describes the clinical features of familial exudative vitreoretinopathy along with the angiographic and genetic screening available to detect and manage this hereditary disease.

Invited Commentary
Diagnosis and Management of Familial Exudative Vitreoretinopathy: A Lifelong, Progressive, and Often Asymmetric Disease
Edward H. Wood, MD; Kimberly A. Drenser, MD, PhD; Antonio Capone Jr, MD

Self-reported Eye Care Use Among US Adults Aged 50 to 80 Years

Joshua R. Ehrlich, MD, MPH; Tochukwu Ndukwe, BS; Erica Solway, PhD, MSW, MPH; et al.

Abstract Full Text

JAMA Ophthalmol. 2019;137(9):1061-1066. doi:10.1001/jamaophthalmol.2019.1927

This cross-sectional online survey study provides nationally representative estimates on self-reported use of eye care by US adults aged 50 to 80 years and describes the reasons that adults do and do not seek eye care.

Motor Vehicle–Associated Traumatic Ocular Injuries Secondary to External Rear-Facing Sideview Mirrors: A Report of 3 Patients

J. Morgan Micheletti, MD; James C. Lockwood, MD; Aditya Rali, MD; et al.

Abstract Full Text

JAMA Ophthalmol. 2019;137(9):1067-1071. doi:10.1001/jamaophthalmol.2019.2513

This case series details ocular trauma caused by shattered glass from sideview mirrors in motor vehicle crashes.

Invited Commentary

Making Progress Toward an Electronic Infrastructure for Ophthalmic Care

Michael F. Chiang, MD

Abstract Full Text

JAMA Ophthalmol. 2019;137(9):975-976. doi:10.1001/jamaophthalmol.2019.1996

Seeking Surrogate Markers for Diabetic Macular Edema

Sapna Gangaputra, MD, MPH; Paul Sternberg Jr, MD

Abstract Full Text

JAMA Ophthalmol. 2019;137(9):985-986. doi:10.1001/jamaophthalmol.2019.1985

Observations and Lessons Learned From the Artificial Intelligence Studies for Diabetic Retinopathy Screening

Daniel Shu Wei Ting, MD, PhD; Lawrence Carin, PhD; Michael D. Abramoff, MD, PhD

Abstract Full Text

JAMA Ophthalmol. 2019;137(9):994-995. doi:10.1001/jamaophthalmol.2019.1997

Insights From 2 Outbreaks in Southeastern Brazil: Yellow Fever Retinopathy

Jessica G. Shantha, MD; Steven Yeh, MD; Nisha Acharya, MD

Abstract Full Text

JAMA Ophthalmol. 2019;137(9):1003-1004. doi:10.1001/jamaophthalmol.2019.1936

Use of Corneal Biomechanical Measures as Endophenotypes for Understanding the Genetics of Keratoconus

Kathryn P. Burdon, PhD, BSc (Hons)

Abstract Full Text

JAMA Ophthalmol. 2019;137(9):1013-1014. doi:10.1001/jamaophthalmol.2019.2068

A Seat at the Operating Room Table in Ophthalmology Surgery

Julia A. Haller, MD; Qiang Zhang, PhD

Abstract Full Text

JAMA Ophthalmol. 2019;137(9):1020-1021. doi:10.1001/jamaophthalmol.2019.2426

Automated Algorithms and Retinopathy of Prematurity Treatment

William V. Good, MD

Abstract Full Text

JAMA Ophthalmol. 2019;137(9):1036-1037. doi:10.1001/jamaophthalmol.2019.2463

Truth, Transparency, and Teaching

R. Michael Siatkowski, MD

Abstract Full Text

JAMA Ophthalmol. 2019;137(9):1052-1053. doi:10.1001/jamaophthalmol.2019.1933

Diagnosis and Management of Familial Exudative Vitreoretinopathy: A Lifelong, Progressive, and Often Asymmetric Disease

Edward H. Wood, MD; Kimberly A. Drenser, MD, PhD; Antonio Capone Jr, MD

Abstract Full Text

JAMA Ophthalmol. 2019;137(9):1059-1060. doi:10.1001/jamaophthalmol.2019.1484

JAMA Ophthalmology Clinical Challenge

Intermittent Temporal Visual Field Loss in a Middle-aged Man

Hasenin Al-Khersan, MD; Natalia Villate, MD; Janet L. Davis, MD

Abstract Full Text

JAMA Ophthalmol. 2019;137(9):1072-1073. doi:10.1001/jamaophthalmol.2019.1638

A middle-aged man presented with recurrent loss of vision in his left temporal field, choroidal thickening in both maculae, and choroidal detachment in the left eye. His condition did not respond to corticosteroids. What would you do next?

Rare Case of Bilateral Orbital Masses

Ajay Malhotra, MD, MMM; Kimberly Seifert, MD; Adeniyi A. Fisayo, MD, PharmD

Abstract Full Text

JAMA Ophthalmol. 2019;137(9):1074-1075. doi:10.1001/jamaophthalmol.2019.1053

A 60-year-old woman with a history of Lyme disease presents with polydipsia and polyuria and a thickening and enhancement of the pituitary gland, stalk, and hypothalamus. What would you do next?

Pigmented Macular Lesion in a Child

Kevin D. Chodnicki, MD; Michael C. Brodsky, MD; Timothy W. Olsen, MD

Abstract Full Text

JAMA Ophthalmol. 2019;137(9):1076-1077. doi:10.1001/jamaophthalmol.2019.1659

A 5-year-old boy with a history of Escherichia coli infection complicated by hemolytic uremic syndrome presents with a homogenous, gray mass in the macula of the right eye. What would you do next?

A Patient With Type 1 Diabetes, Visual Acuity Loss, and Retinal Thickening

Anat Loewenstein, MD, MHA; Jean-François Korobelnik, MD; Annabelle A. Okada, MD, DMSc

Abstract Full Text

JAMA Ophthalmol. 2019;137(9):1078-1079. doi:10.1001/jamaophthalmol.2019.2137

A young man with type 1 diabetes presents with loss of visual acuity and optical coherence tomography–confirmed retinal thickening in the macular area. What would you do next?

Bilateral Loss of Vision a Few Hours After a Motor Vehicle Crash

Frédéric Villard, MD; Gabriele Thumann, MD, PHD; Ariane Malclès, MD

Abstract Full Text

JAMA Ophthalmol. 2019;137(9):1080-1081. doi:10.1001/jamaophthalmol.2019.2674

A 74-year-old woman was referred for a bilateral blurry vision occurring 2 hours after a car crash.

Observation

Intravitreal Methotrexate for Recurrent Epithelial Downgrowth

Nathan G. Lambert, MD; David J. Wilson, MD; Daniel M. Albert, MD, MS; et al.

Abstract Full Text

JAMA Ophthalmol. 2019;137(9):1082-1083. doi:10.1001/jamaophthalmol.2019.2151

This case reports details treatment of epithelial downgrowth with methotrexate in a man who had not experienced relief with multiple other procedures.

Capturing Macular Vascular Development in an Infant With Retinopathy of Prematurity

Xi Chen, MD, PhD; Christian Viehland, PhD; Du Tran-Viet, BS; et al.

Abstract Full Text

JAMA Ophthalmol. 2019;137(9):1083-1086. doi:10.1001/jamaophthalmol.2019.2165

This case report describes bedside handheld optical coherence tomography findings in a premature infant who was screened for retinopathy of prematurity.

Association of Nonuveitic Retinal Vasculitis and Tractional Retinoschisis With Cystoid Macular Edema With Fabry Disease

C. Ellis Wisely, MD; Jong G. Park, MD; Scott D. Walter, MD, MSc; et al.

Abstract Full Text

JAMA Ophthalmol. 2019;137(9):1086-1088. doi:10.1001/jamaophthalmol.2019.2170

This case report describes a 62-year-old woman with Fabry disease that was associated with nouveitic retinal vasculitis and tractional retinoschisis.

Bilateral Mydriasis and Serous Retinal Detachments Associated With Ipilimumab and 6-Melanoma Helper Peptide Vaccine for Cutaneous Melanoma

Christina Rodriguez, MD; Rebecca Sieburth, MD; Steven Newman, MD; et al.

Abstract Full Text

JAMA Ophthalmol. 2019;137(9):1088-1090. doi:10.1001/jamaophthalmol.2019.2451

This case report describes a woman whose participation in a clinical trial for melanoma treatment was interrupted by common and unusual adverse effects.

Ophthalmic Images

Explosive Ocular Trauma Caused by Celebratory Fireworks

Yao Ni, MD; Zhaohui Yuan, MD

Abstract Full Text

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JAMA Ophthalmol. 2019;137(9):e185824. doi:10.1001/jamaophthalmol.2018.5824

This case report describes a boy and a girl, both with damage to their eyes caused by fireworks.

Bergmeister Papilla With Overlying Traction

Nandini Venkateswaran, MD; Stephen Justin Moster, MD; Brian Evan Goldhagen, MD

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JAMA Ophthalmol. 2019;137(9):e185915. doi:10.1001/jamaophthalmol.2018.5915

This case report describes a Bergmeister papilla on the right optic nerve with traction on vessels and the macula and optic nerve elevation with traction creating macular schisis.