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February 2020 - January 1929

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February 2020, Vol 138, No. 2, Pages 111-223

In This Issue of JAMA Ophthalmology

Highlights

Abstract Full Text
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JAMA Ophthalmol. 2020;138(2):111. doi:10.1001/jamaophthalmol.2019.3836
Original Investigation

Association of Postfungal Keratitis Corneal Scar Features With Visual Acuity

Abstract Full Text
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JAMA Ophthalmol. 2020;138(2):113-118. doi:10.1001/jamaophthalmol.2019.4852

This cross-sectional study investigates which features of a typical postfungal keratitis corneal scar are most associated with vision loss and evaluates the use of corneal imaging metrics as cornea-specific outcomes for clinical studies.

Prevalence and Severity of Artifacts in Optical Coherence Tomographic Angiograms

Abstract Full Text
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JAMA Ophthalmol. 2020;138(2):119-126. doi:10.1001/jamaophthalmol.2019.4971

This cross-sectional study evaluates operational- and patient-related artifacts present in optical coherence tomography angiograms of eyes with diabetic retinopathy.

Association of Messenger RNA Level With Phenotype in Patients With Choroideremia: Potential Implications for Gene Therapy Dose

Abstract Full Text
JAMA Ophthalmol. 2020;138(2):128-135. doi:10.1001/jamaophthalmol.2019.5071

This case series study analyzes CHM messenger RNA splicing outcomes in 2 unrelated patients with c.940+3delA CHM splice site variants.

Visual Outcome at 4 Years Following Plaque Radiotherapy and Prophylactic Intravitreal Bevacizumab (Every 4 Months for 2 Years) for Uveal Melanoma: Comparison With Nonrandomized Historical Control Individuals

Abstract Full Text
JAMA Ophthalmol. 2020;138(2):136-146. doi:10.1001/jamaophthalmol.2019.5132

This cohort study investigates 4-year visual outcomes following prophylactic intravitreal bevacizumab, injected at 4-month intervals over 2 years, in patients with plaque-irradiated uveal melanoma.

Vascular Changes in the Retina and Choroid of Patients With EPAS1 Gain-of-Function Mutation Syndrome

Abstract Full Text
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JAMA Ophthalmol. 2020;138(2):148-155. doi:10.1001/jamaophthalmol.2019.5244

This case series describes the venous vasculature in the hyaloid, retinal, and choroidal layers in patients with the EPAS1 gain-of-function mutation syndrome.

Association of Rhegmatogenous Retinal Detachment and Outcomes With the Day of the Week That Patients Undergo a Repair or Receive a Diagnosis

Abstract Full Text
JAMA Ophthalmol. 2020;138(2):156-163. doi:10.1001/jamaophthalmol.2019.5253

This cohort study assesses the association between modality of rhegmatogenous retinal detachment repair and the day of the week that patients receive a diagnosis or undergo retinal detachment repair.

Optic Disc Edema and Choroidal Engorgement in Astronauts During Spaceflight and Individuals Exposed to Bed Rest

Abstract Full Text
JAMA Ophthalmol. 2020;138(2):165-172. doi:10.1001/jamaophthalmol.2019.5261

This cohort study examines whether the ocular changes in individuals exposed to an analogue of weightlessness are similar to the ocular changes in astronauts exposed to a duration of spaceflight comparable to this analogue of weightlessness.

Association of Genetic Variation With Keratoconus

Abstract Full Text
JAMA Ophthalmol. 2020;138(2):174-181. doi:10.1001/jamaophthalmol.2019.5293

This case-control, genome-wide association study assesses genetic susceptibility regions for keratoconus via a genome-wide association study of a discovery cohort and 3 independent replication cohorts from the United States, Northern Ireland, and Australia.

Association of Partial Chromosome 3 Deletion in Uveal Melanomas With Metastasis-Free Survival

Abstract Full Text
JAMA Ophthalmol. 2020;138(2):182-188. doi:10.1001/jamaophthalmol.2019.5403

This cohort study of patients with uveal melanomas with and without partial loss of chromosome 3 examines the association of partial chromosome 3 deletion in uveal melanomas with metastasis-free survival.

Characterization of Central Visual Field Loss in End-stage Glaucoma by Unsupervised Artificial Intelligence

Abstract Full Text
JAMA Ophthalmol. 2020;138(2):190-198. doi:10.1001/jamaophthalmol.2019.5413

This cohort study provides a quantitative characterization and classification of central visual field loss among patients with end-stage glaucoma.

Brief Report

Reanalysis of Association of Pro50Leu Substitution in Guanylate Cyclase Activating Protein-1 With Dominant Retinal Dystrophy

Abstract Full Text
JAMA Ophthalmol. 2020;138(2):200-203. doi:10.1001/jamaophthalmol.2019.4959

This cross-sectional study reevaluates a previously reported family in whom the p.(Pro50Leu) variant in the gene GUCA1A was associated with a dominant retinal dystrophy, in light of new examination findings in the proband’s daughter.

Invited Commentary

Pearls and Pitfalls of Optical Coherence Tomography Angiography Image Interpretation

Abstract Full Text
JAMA Ophthalmol. 2020;138(2):126-127. doi:10.1001/jamaophthalmol.2019.5099

Studies Evaluating Visual Outcomes After Brachytherapy in Uveal Melanoma—Strengths and Limitations of Current Investigations

Abstract Full Text
JAMA Ophthalmol. 2020;138(2):146-147. doi:10.1001/jamaophthalmol.2019.5122

Do Rhegmatogenous Retinal Detachment Repair and Outcomes Vary by Day of the Week?

Abstract Full Text
JAMA Ophthalmol. 2020;138(2):163-164. doi:10.1001/jamaophthalmol.2019.5300

Possible Factors Associated With Spaceflight-Associated Neuro-ocular Syndrome

Abstract Full Text
JAMA Ophthalmol. 2020;138(2):172-173. doi:10.1001/jamaophthalmol.2019.5365

Importance of Partial Losses of Chromosome 3 in Uveal Melanoma in the BAP1 Gene Region

Abstract Full Text
JAMA Ophthalmol. 2020;138(2):188-189. doi:10.1001/jamaophthalmol.2019.5491

Central Visual Field Loss in End-stage Glaucoma

Abstract Full Text
JAMA Ophthalmol. 2020;138(2):198-199. doi:10.1001/jamaophthalmol.2019.5494
JAMA Ophthalmology Clinical Challenge

Atypical Conjunctival Lesion Associated With a Bladder Problem

Abstract Full Text
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JAMA Ophthalmol. 2020;138(2):204-205. doi:10.1001/jamaophthalmol.2019.4596

A man in his 70s had an enlarging fleshy nodule of the right nasal conjunctiva and a foreign body sensation on his right eye for 2 weeks. The ophthalmologist prescribed a 3-week course of oral prednisone, but the lesion did not change in appearance. What is your diagnosis?

Acute Promyelocytic Leukemia With Sudden Vision Loss

Abstract Full Text
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JAMA Ophthalmol. 2020;138(2):206-207. doi:10.1001/jamaophthalmol.2019.4838

A 51-year-old man recently diagnosed as having acute promyelocytic leukemia, undergoing induction therapy with all-trans-retinoic acid and arsenic trioxide, which were started 2 weeks prior, presented with sudden loss of vision. What would you do next?

Subacute Vision Loss in a Patient With Limited Immune Dysfunction

Abstract Full Text
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JAMA Ophthalmol. 2020;138(2):208-209. doi:10.1001/jamaophthalmol.2019.4915

A 62-year-old man presents with subacute, painless vision loss in the right eye that developed over the course of 1 week, and a history of well-controlled type 2 diabetes and diffuse large B-cell lymphoma. What would you do next?

Infectious Keratitis in a 23-Year-Old Patient With Netherton Syndrome

Abstract Full Text
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JAMA Ophthalmol. 2020;138(2):210-211. doi:10.1001/jamaophthalmol.2019.4920

A 23-year-old man with Netherton syndrome presents with a history of herpes simplex keratitis and bacterial cultures positive for methicillin-resistant Staphylococcus aureus and Escherichia coli. What would you do next?

Research Letter

Trends in Employment by Dual Sensory Impairment Status

Abstract Full Text
JAMA Ophthalmol. 2020;138(2):213-215. doi:10.1001/jamaophthalmol.2019.4955

This study compares employment rates by vision impairment, hearing impairment, and dual sensory impairment using data from the National Health Interview Survey from the 2008 to 2017 cycles.

Observation

Lens Opacity Following High-Intensity Focused Ultrasound

Abstract Full Text
JAMA Ophthalmol. 2020;138(2):215-216. doi:10.1001/jamaophthalmol.2019.4963

This case report describes deterioration of visual acuity associated with damage from high-intensity focused ultrasound treatment applied inappropriately to the eyelids.

Retinal Neovascularization–Simulating Retinal Capillary Reperfusion in Branch Retinal Vein Occlusion, Imaged by Wide-Field Optical Coherence Tomography Angiography

Abstract Full Text
JAMA Ophthalmol. 2020;138(2):216-218. doi:10.1001/jamaophthalmol.2019.5018

This case report describes a woman who experienced retinal neovascularization, a complication of branch retinal vein occlusion, manifesting with retinal nonperfusion, covered by retinal neovascularization, and appearing as retinal capillary reperfusion.

Inner Retinal Dimpling After Endophthalmitis and Vitrectomy Without Internal Limiting Membrane Peeling

Abstract Full Text
JAMA Ophthalmol. 2020;138(2):218-221. doi:10.1001/jamaophthalmol.2019.5061

This case report discusses an instance of inner retinal dimpling after endophthalmitis and vitrectomy without internal limiting membrane peeling and how this observation provides further insight into the pathophysiology of this phenomenon.

Optical Coherence Tomography Angiography Recovery Pattern of Acute Macular Neuroretinopathy

Abstract Full Text
JAMA Ophthalmol. 2020;138(2):221-223. doi:10.1001/jamaophthalmol.2019.5066

This case report describes a 73-year-old man with acute vision loss in his right eye following pacemaker dysfunction during the early postimplantation period who was diagnosed as having acute macular neuroretinopathy.

Ophthalmic Images

Anterior Segment Optical Coherence Tomography Angiography of Iris Neovascularization After Intravitreal Ranibizumab and Panretinal Photocoagulation

Abstract Full Text
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JAMA Ophthalmol. 2020;138(2):e190318. doi:10.1001/jamaophthalmol.2019.0318

This case report describes images of iris neovascularization in the superficial and deep layers before treatment and after intravitreal ranibizumab and panretinal photocoagulation.

Ultra-Widefield Laser Scanning Retina Imaging in Oculocutaneous Albinism

Abstract Full Text
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JAMA Ophthalmol. 2020;138(2):e190399. doi:10.1001/jamaophthalmol.2019.0399

This case report describes a girl with abnormalities of the skin and hair that were consistent with albinism.

Posttraumatic Intracorneal Iris Herniation Mimicking a Pigmented Limbal Lesion

Abstract Full Text
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JAMA Ophthalmol. 2020;138(2):e190557. doi:10.1001/jamaophthalmol.2019.0557

This case report describes iris protrusion with a mild corneal opacity and intracorneal iris herniation encapsulated within an intracorneal cavity with hyperreflective walls.

Successful Treatment of Exuberant Conjunctival Squamous Papilloma

Abstract Full Text
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JAMA Ophthalmol. 2020;138(2):e190930. doi:10.1001/jamaophthalmol.2019.0930

This case report describes a case of exuberant conjunctival squamous papilloma.

Comment & Response

Association Between Migraine Headaches and Dry Eye Disease in Patients Studied in General Practices in Germany

Abstract Full Text
JAMA Ophthalmol. 2020;138(2):223. doi:10.1001/jamaophthalmol.2019.5106
Correction

Error in Text

Abstract Full Text
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JAMA Ophthalmol. 2020;138(2):223. doi:10.1001/jamaophthalmol.2019.5335

Error in Text

Abstract Full Text
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JAMA Ophthalmol. 2020;138(2):223. doi:10.1001/jamaophthalmol.2019.5526

Error in the Author Affiliation

Abstract Full Text
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JAMA Ophthalmol. 2020;138(2):223. doi:10.1001/jamaophthalmol.2019.5606
JAMA Ophthalmology Masthead

JAMA Ophthalmology

Abstract Full Text
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JAMA Ophthalmol. 2020;138(2):112. doi:10.1001/jamaophthalmol.2019.3837
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