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November 2021 - January 1929

Decade

Year

Issue

April 2021, Vol 139, No. 4, Pages 379-489

Viewpoint

What Is Just the Right Amount of Anti–Vascular Endothelial Growth Factor Treatment for Diabetic Macular Edema?Protocol V and the Goldilocks Principle

Abstract Full Text
JAMA Ophthalmol. 2021;139(4):381-382. doi:10.1001/jamaophthalmol.2021.0013

This Viewpoint asks what is the maximum that can be done to prevent vision loss in patients with diabetic macular edema.

Original Investigation

Presence of SARS-CoV-2 RNA in the Cornea of Viremic Patients With COVID-19

Abstract Full Text
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JAMA Ophthalmol. 2021;139(4):383-388. doi:10.1001/jamaophthalmol.2020.6339

This case series investigates the presence of viral severe acute respiratory syndrome coronavirus 2 RNA in corneal discs of deceased patients with confirmed coronavirus disease 2019 and assesses viral genomic and subgenomic RNA load, possible infectivity, and histologic abnormalities.

Opportunities to Reduce Potential Bias in Ophthalmic Cost-Utility Analysis

Abstract Full Text
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JAMA Ophthalmol. 2021;139(4):389-397. doi:10.1001/jamaophthalmol.2020.6591

This economic evaluation assesses whether use of nonpatient vision utilities and a maximum limit model constraining vision utility gain to the systemic comorbidity utility level biases against ophthalmic cost-utility outcomes among patients with neovascular age-related macular degeneration and cataract.

Assessment of Trends in the Incidence Rates of Central Retinal Artery Occlusion in Korea From 2002 to 2015

Abstract Full Text
JAMA Ophthalmol. 2021;139(4):399-405. doi:10.1001/jamaophthalmol.2020.6860

This cohort study uses data from the Korean National Health Insurance Service database from 2002 to 2015 to estimate temporal trends in the incidence rates of central retinal artery occlusion among residents of Korea.

Discordance Rate Among Bilateral Simultaneous and Sequential Temporal Artery Biopsies in Giant Cell Arteritis: Role of Frozen Sectioning Based on the Mayo Clinic Experience

Abstract Full Text
JAMA Ophthalmol. 2021;139(4):406-413. doi:10.1001/jamaophthalmol.2020.6896

This cohort study evaluates the sensitivity and specificity of temporal artery biopsy frozen vs permanent section pathology results for giant cell arteritis and determines the discordance rate of bilateral temporal artery biopsies.

Tuberculosis Exposure With Risk of Behçet Disease Among Patients With Uveitis

Abstract Full Text
JAMA Ophthalmol. 2021;139(4):415-422. doi:10.1001/jamaophthalmol.2020.6985

This mendelian randomization and cohort study evaluates associations of tuberculosis with several noninfectious uveitis conditions, particularly Behçet disease, in cohorts in China and Japan, including a subgroup given T-SPOT.TB assays.

Predicting Edema Resolution After Descemet Membrane Endothelial Keratoplasty for Fuchs Dystrophy Using Scheimpflug Tomography

Abstract Full Text
JAMA Ophthalmol. 2021;139(4):423-430. doi:10.1001/jamaophthalmol.2020.6994

This prognostic study develops a predictive model in which Scheimpflug tomographic imaging is used to evaluate edema resolution after Descemet membrane endothelial keratoplasty in patients with advanced Fuchs dystrophy.

Prevalence and Factors Associated With Eyeglass Wear Compliance Among Preschoolers From Low-Income Families in San Francisco, California

Abstract Full Text
JAMA Ophthalmol. 2021;139(4):433-440. doi:10.1001/jamaophthalmol.2020.7053

This cross-sectional study assesses the prevalence and factors associated with eyeglass wear compliance for a school year among preschool children who have a failed vision screening, are from low-income families, and receive eyeglasses through the See Well to Learn program.

Early Experience With Brolucizumab Treatment of Neovascular Age-Related Macular Degeneration

Abstract Full Text
JAMA Ophthalmol. 2021;139(4):441-448. doi:10.1001/jamaophthalmol.2020.7085

This case series reports clinical outcomes after intravitreous injection of brolucizumab, 6 mg, for neovascular age-related macular degeneration.

Association of No-Cost Genetic Testing Program Implementation and Patient Characteristics With Access to Genetic Testing for Inherited Retinal Degenerations

Abstract Full Text
JAMA Ophthalmol. 2021;139(4):449-455. doi:10.1001/jamaophthalmol.2021.0004

This cross-sectional study examines the use of no-cost genetic testing in patients with inherited retinal degeneration.

Frequency of Urgent or Emergent Vitreoretinal Surgical Procedures in the United States During the COVID-19 Pandemic

Abstract Full Text
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JAMA Ophthalmol. 2021;139(4):456-463. doi:10.1001/jamaophthalmol.2021.0036

This cross-sectional study evaluates whether the frequency of ophthalmic surgical procedures deemed urgent or emergent by the American Academy of Ophthalmology changed across the United States during the coronavirus disease 2019 pandemic.

Overminus Lens Therapy for Children 3 to 10 Years of Age With Intermittent Exotropia: A Randomized Clinical Trial

Abstract Full Text
has active quiz has audio
JAMA Ophthalmol. 2021;139(4):464-476. doi:10.1001/jamaophthalmol.2021.0082

This randomized clinical trial evaluates whether wearing followed by weaning off overminus spectacles improves distance control in children 3 to 10 years of age with intermittent exotropia.

Invited Commentary

Calculating Utility Gain by Different Methods for the Treatment of Cataract or Neovascular Age-Related Macular Degeneration: What Are the Consequences?

Abstract Full Text
JAMA Ophthalmol. 2021;139(4):397-398. doi:10.1001/jamaophthalmol.2020.6584

Is It Always Better to Get Faster Results in Temporal Artery Biopsies?

Abstract Full Text
JAMA Ophthalmol. 2021;139(4):413-414. doi:10.1001/jamaophthalmol.2020.6895

Toward a Paradigm Shift in the Therapeutic Approach to Fuchs Endothelial Corneal Dystrophy

Abstract Full Text
JAMA Ophthalmol. 2021;139(4):431-432. doi:10.1001/jamaophthalmol.2020.7041

Overminus Lens Therapy for Children With Intermittent Exotropia

Abstract Full Text
JAMA Ophthalmol. 2021;139(4):476-477. doi:10.1001/jamaophthalmol.2021.0081
JAMA Ophthalmology Clinical Challenge

White Macula After Pars Plana Vitrectomy in a 71-Year-Old Woman

Abstract Full Text
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JAMA Ophthalmol. 2021;139(4):478-479. doi:10.1001/jamaophthalmol.2020.4616

Three weeks after uneventful pars plana vitrectomy of the right eye for vitreomacular traction, a 71-year-old woman presents with a painless central scotoma and worsening floaters. Optical coherence tomography shows atrophy, full-thickness hyperreflectivity, and a residual epiretinal membrane. What would you do next?

Nonclearing Corneal Edema After Phacoemulsification and Intraocular Lens Implantation

Abstract Full Text
has active quiz
JAMA Ophthalmol. 2021;139(4):480-481. doi:10.1001/jamaophthalmol.2020.4660

An 82-year-old man presents with a history of bilateral nuclear sclerotic cataracts and blurred vision in the right eye after cataract extraction 8 weeks earlier. On examination, his best-corrected visual acuity is 20/80 OD and 20/20 OS with a few guttate in the left eye, and central corneal thickness is 957 and 547 μm in the right and left eyes, respectively. What would you do next?

A 47-Year-Old Woman Urgently Referred for Proliferative Diabetic Retinopathy Management

Abstract Full Text
has active quiz
JAMA Ophthalmol. 2021;139(4):482-483. doi:10.1001/jamaophthalmol.2020.4670

A woman with type 2 diabetes and acute onset of blurry vision was referred for possible proliferative diabetic management. What would you do next?

Unilateral Frosted Branch Angiitis in a Patient With Immunosuppression

Abstract Full Text
has active quiz
JAMA Ophthalmol. 2021;139(4):484-485. doi:10.1001/jamaophthalmol.2020.4684

A 49-year-old man presents with acute unilateral painless vision loss, antisynthetase syndrome, fever, and interstitial lung disease. What would you do next?

Research Letter

Association of Macular Optical Coherence Tomography Measures and Deficits in Facial Recognition in Patients With Glaucoma

Abstract Full Text
JAMA Ophthalmol. 2021;139(4):486-487. doi:10.1001/jamaophthalmol.2021.0137

This study investigates the association between facial recognition and macular structural damage, as measured by spectral-domain ocular coherence tomography retinal ganglion cell and inner plexiform layer.

Ophthalmic Images

Cutaneous Malignant Melanoma Metastatic to the Intraocular Lens

Abstract Full Text
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JAMA Ophthalmol. 2021;139(4):e210017. doi:10.1001/jamaophthalmol.2021.0017

This case report describes a rare case of cutaneous malignant melanoma metastatic to the intraocular lens.

Perforation of Presumed Papillary Gliosis Resulting in an Optic Pit in a Child

Abstract Full Text
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JAMA Ophthalmol. 2021;139(4):e210246. doi:10.1001/jamaophthalmol.2021.0246

This case report describes change over time in a translucent, gliotic-appearing membrane overlying the left optic nerve that first appeared in a 16-month-old boy.

Ocular Relapse of B-Cell Acute Lymphoblastic Leukemia

Abstract Full Text
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JAMA Ophthalmol. 2021;139(4):e210514. doi:10.1001/jamaophthalmol.2021.0514

This case report describes a relapse of B-cell acute lymphoblastic leukemia/lymphoma that initially presented as uveitis.

A Spiderweb-Like Fibrinous Reaction

Abstract Full Text
online only
JAMA Ophthalmol. 2021;139(4):e210697. doi:10.1001/jamaophthalmol.2021.0697

This case report describes a man who experienced a postsurgical, spiderweb-like formation in the anterior chamber of an eye treated for cataract.

Comment & Response

Do Racial/Ethnic Disparities in Rates of Enucleation for Uveal Melanoma Indicate Poor Quality of Care or Financial Obstacles?

Abstract Full Text
JAMA Ophthalmol. 2021;139(4):487-488. doi:10.1001/jamaophthalmol.2020.6828

Do Racial/Ethnic Disparities in Rates of Enucleation for Uveal Melanoma Indicate Poor Quality of Care or Financial Obstacles?—Reply

Abstract Full Text
JAMA Ophthalmol. 2021;139(4):488-489. doi:10.1001/jamaophthalmol.2020.6831
Correction

Replacement of Nonauthor Collaborator Names

Abstract Full Text
free access
JAMA Ophthalmol. 2021;139(4):489. doi:10.1001/jamaophthalmol.2021.0124
JAMA Ophthalmology Masthead

JAMA Ophthalmology

Abstract Full Text
free access
JAMA Ophthalmol. 2021;139(4):379. doi:10.1001/jamaophthalmol.2020.3755
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