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October 2021 - January 1929

Decade

Year

Issue

May 2021, Vol 139, No. 5, Pages 497-589

Editorial

JAMA Ophthalmology—The Year in Review, 2020: Bringing Focus to Randomized Clinical Trials

Abstract Full Text
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JAMA Ophthalmol. 2021;139(5):499-500. doi:10.1001/jamaophthalmol.2021.0272
Original Investigation

Topographical Response of Retinal Neovascularization to Aflibercept or Panretinal Photocoagulation in Proliferative Diabetic Retinopathy: Post Hoc Analysis of the CLARITY Randomized Clinical Trial

Abstract Full Text
open access
JAMA Ophthalmol. 2021;139(5):501-507. doi:10.1001/jamaophthalmol.2021.0108

This post hoc analysis of the CLARITY randomized clinical trial investigates the distribution of neovascularization in patients with proliferative diabetic retinopathy and the topographical response of neovascularization to treatment with aflibercept or panretinal photocoagulation.

Patient Perceptions of SARS-CoV-2 Exposure Risk and Association With Continuity of Ophthalmic Care

Abstract Full Text
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JAMA Ophthalmol. 2021;139(5):508-515. doi:10.1001/jamaophthalmol.2021.0114

This survey study uses data from a random sample of patients from 2 tertiary eye care centers to investigate the association of missed ophthalmic appointments with patient fear of contracting the coronavirus disease 2019 virus, SARS-CoV-2.

Cost Savings From a Policy to Diagnose and Prevent Transmission of Adenoviral Conjunctivitis in Employees of a Large Academic Medical Center

Abstract Full Text
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JAMA Ophthalmol. 2021;139(5):518-524. doi:10.1001/jamaophthalmol.2021.0150

This quality improvement study examines the institutional cost savings of a policy to diagnose adenoviral conjunctivitis and triage and furlough medical center employees with suspected adenoviral conjunctivitis to prevent outbreaks.

A Global Assessment of Eye Health and Quality of Life: A Systematic Review of Systematic Reviews

Abstract Full Text
open access
JAMA Ophthalmol. 2021;139(5):526-541. doi:10.1001/jamaophthalmol.2021.0146

This cross-sectional study examines the association between vision impairment or eye disease and quality of life and the outcome of ophthalmic interventions on quality of life globally and across the life span.

Intravitreal Aflibercept Injection vs Sham as Prophylaxis Against Conversion to Exudative Age-Related Macular Degeneration in High-risk Eyes: A Randomized Clinical Trial

Abstract Full Text
JAMA Ophthalmol. 2021;139(5):542-547. doi:10.1001/jamaophthalmol.2021.0221

This randomized clinical trial evaluates the use of intravitreal aflibercept as prophylaxis against conversion to exudative age-related macular degeneration (AMD) in patients with dry AMD and high risk for conversion.

Association of Retinal Changes With Alzheimer Disease Neuroimaging Biomarkers in Cognitively Normal Individuals

Abstract Full Text
JAMA Ophthalmol. 2021;139(5):548-556. doi:10.1001/jamaophthalmol.2021.0320

This cross-sectional study examines the use of structural changes in the retina as biomarkers to identify amyloid-β deposition in assessment of individuals for preclinical Alzheimer disease.

Assessment of Cumulative Incidence and Severity of Primary Open-Angle Glaucoma Among Participants in the Ocular Hypertension Treatment Study After 20 Years of Follow-up

Abstract Full Text
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JAMA Ophthalmol. 2021;139(5):558-566. doi:10.1001/jamaophthalmol.2021.0341

This cohort study comprises phase 3 of the Ocular Hypertension Treatment Study and assesses the 20-year cumulative incidence and severity of primary open-angle glaucoma among the original cohort of participants with ocular hypertension.

Preterm Infant Stress During Handheld Optical Coherence Tomography vs Binocular Indirect Ophthalmoscopy Examination for Retinopathy of Prematurity

Abstract Full Text
JAMA Ophthalmol. 2021;139(5):567-574. doi:10.1001/jamaophthalmol.2021.0377

This cross-sectional study compares stress during investigational optical coherence tomography imaging to that during binocular indirect ophthalmoscopy for retinopathy of prematurity.

Invited Commentary

The Importance of Patients’ Perspectives in Providing Ophthalmic Care—Lessons From the COVID-19 Pandemic

Abstract Full Text
free access has active quiz
JAMA Ophthalmol. 2021;139(5):516-517. doi:10.1001/jamaophthalmol.2021.0121

Keeping Red Eyes From Putting Workplaces in the Red

Abstract Full Text
JAMA Ophthalmol. 2021;139(5):524-525. doi:10.1001/jamaophthalmol.2021.0144

Structural and Functional Retinal Changes in Preclinical Alzheimer Disease

Abstract Full Text
JAMA Ophthalmol. 2021;139(5):556-557. doi:10.1001/jamaophthalmol.2021.0319
JAMA Ophthalmology Clinical Challenge

Unilateral Hypopyon in an Elderly Man With Dementia

Abstract Full Text
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JAMA Ophthalmol. 2021;139(5):575-576. doi:10.1001/jamaophthalmol.2020.4633

An elderly man with a history of Philadelphia chromosome–positive acute lymphocytic leukemia, diabetes, and dementia presented with decreased visual acuity and hypopyon in his right eye. What would you do next?

Painless Visual Loss in a Septuagenarian

Abstract Full Text
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JAMA Ophthalmol. 2021;139(5):577-578. doi:10.1001/jamaophthalmol.2020.4638

A septuagenarian with a history of Crohn disease, coronary artery disease, hypercholesterolemia, and transient ischemic attack presents with sudden, painless visual loss. Examination of a temporal artery biopsy specimen shows chronic, nongranulomatous inflammation. Reexamination of the biopsy specimen 2 weeks later shows abundant transmural deposits of amorphous eosinophilic acellular material that exhibit apple-green birefringence consistent with amyloid deposits; IgM and lambda light chain restriction are also observed. What would you do next?

Bilateral Asymmetrical Corneal Deposits in an Asymptomatic Patient

Abstract Full Text
has active quiz
JAMA Ophthalmol. 2021;139(5):579-580. doi:10.1001/jamaophthalmol.2020.4656

A 70-year-old woman presented with a history of hypertension, hyperlipidemia, and bilateral asymmetric corneal lesions. What is your diagnosis?

Retinal Detachment in a 40-Year-Old Man With Sturge-Weber Syndrome

Abstract Full Text
has active quiz
JAMA Ophthalmol. 2021;139(5):581-582. doi:10.1001/jamaophthalmol.2020.4665

A 40-year-old man presents with decreased vision 3 weeks after undergoing a 2-stage Baerveldt implantation. Ocular history shows Sturge-Weber syndrome, secondary glaucoma, and chronic retinal detachment. Examination showed a red glow of the fundus with shifting subretinal fluid and retinal detachment in the left eye, and retinal detachment and demonstrated homogeneous diffuse choroidal thickening in the right eye. What would you do next?

Research Letter

MOG-IgG Among Participants in the Pediatric Optic Neuritis Prospective Outcomes Study

Abstract Full Text
JAMA Ophthalmol. 2021;139(5):583-585. doi:10.1001/jamaophthalmol.2021.0349

This study examines the association of myelin oligodendrocyte glycoprotein immunoglobulin G–associated disorder with pediatric optic neuritis to guide prognosis and treatment.

Observation

Association of Conjunctival Plaques With BRAF Inhibitor Treatment in Patients With Pediatric Brain Tumor

Abstract Full Text
JAMA Ophthalmol. 2021;139(5):585-586. doi:10.1001/jamaophthalmol.2021.0169

These case reports investigate the potential association between BRAF inhibitors and conjunctival plaques in patients with pediatric brain tumor.

Ophthalmic Images

An Unusual, Idiopathic Scrolled Epiretinal Membrane

Abstract Full Text
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JAMA Ophthalmol. 2021;139(5):e211146. doi:10.1001/jamaophthalmol.2021.1146

This case report describes a woman with an unusual, idiopathic epiretinal membrane visible on multiple types of imaging.

Comment & Response

An Emphasis on the Gap Between the Surveyed Myopia Rate and Eyeglass-Wearing Rate in the Study of Ocular Susceptibility to SARS-CoV-2 Infection

Abstract Full Text
JAMA Ophthalmol. 2021;139(5):586-587. doi:10.1001/jamaophthalmol.2021.0494

An Emphasis on the Gap Between the Surveyed Myopia Rate and Eyeglass-Wearing Rate in the Study of Ocular Susceptibility to SARS-CoV-2 Infection—Reply

Abstract Full Text
JAMA Ophthalmol. 2021;139(5):587-588. doi:10.1001/jamaophthalmol.2021.0511

Survival Analysis vs Longitudinal Modeling With Multiple Imputation—A False Dichotomy

Abstract Full Text
JAMA Ophthalmol. 2021;139(5):588. doi:10.1001/jamaophthalmol.2021.0508

Survival Analysis vs Longitudinal Modeling With Multiple Imputation—a False Dichotomy—Reply

Abstract Full Text
JAMA Ophthalmol. 2021;139(5):588-589. doi:10.1001/jamaophthalmol.2021.0518
Peer Reviewers List

JAMA Ophthalmology Peer Reviewers in 2020

Abstract Full Text
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JAMA Ophthalmol. 2021;139(5):e210188. doi:10.1001/jamaophthalmol.2021.0188
JAMA Ophthalmology Masthead

JAMA Ophthalmology

Abstract Full Text
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JAMA Ophthalmol. 2021;139(5):497. doi:10.1001/jamaophthalmol.2020.3761
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