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Year

Day

October 22, 2020
Original Investigation

Mesopic and Scotopic Light Sensitivity and Its Microstructural Correlates in Pseudoxanthoma Elasticum

Abstract Full Text
JAMA Ophthalmol. Published online October 22, 2020. doi:10.1001/jamaophthalmol.2020.4335

This case-control study examines the use of mesopic and dark-adapted microperimetry as functional outcome measures in patients with pseudoxanthoma elasticum.

Using Optical Coherence Tomography as a Surrogate of Measurements of Intracranial Pressure in Idiopathic Intracranial Hypertension

Abstract Full Text
JAMA Ophthalmol. Published online October 22, 2020. doi:10.1001/jamaophthalmol.2020.4242

This study of 2 cohorts aims to determine whether optical coherence tomography of the optic nerve head in papilledema could act as a surrogate measure of intracranial pressure.

Brief Report

Self-perception in Preschool Children With Deprivation Amblyopia and Its Association With Deficits in Vision and Fine Motor Skills

Abstract Full Text
JAMA Ophthalmol. Published online October 22, 2020. doi:10.1001/jamaophthalmol.2020.4363

This study evaluates whether deprivation amblyopia is associated with altered self-perception in preschool children and to determine whether any differences in self-perception are associated with vision or motor skill deficits.

Invited Commentary

Beyond Visual Acuity—The Importance of Studying Motor Skills and Self-perception in Children Treated for Unilateral Congenital Cataract

Abstract Full Text
JAMA Ophthalmol. Published online October 22, 2020. doi:10.1001/jamaophthalmol.2020.4332
JAMA Ophthalmology Clinical Challenge

An Unusual Upper Eyelid Mass

Abstract Full Text
has active quiz
JAMA Ophthalmol. Published online October 22, 2020. doi:10.1001/jamaophthalmol.2020.2859

A 67-year-old woman seeks evaluation of nontender periauricular fullness in the left upper eyelid 2 months after surgical drainage of swelling in the same area, which was believed to be a chalazion. Magnetic resonance imaging of the orbit and parotid glands reveals focal enhancement in the left upper eyelid and the superficial lobe of the left parotid gland. What would you do next?

Observation

Delayed Recovery of Corneal Nerve Function and Structure Following Acoustic Neuroma Surgery

Abstract Full Text
JAMA Ophthalmol. Published online October 22, 2020. doi:10.1001/jamaophthalmol.2020.4279

This case report describes a woman in her 30s who presented to an eye emergency department with left-sided reduced vision and redness after treatment for a cerebellopontine angle tumor.

A Case of Metastatic Giant Cell Tumor of Soft Tissue of the Orbit Associated With PALB2 Variant

Abstract Full Text
JAMA Ophthalmol. Published online October 22, 2020. doi:10.1001/jamaophthalmol.2020.4308

This case report describes a woman in her 30s with a history of nodular sclerosing type stage IIE Hodgkin lymphoma who presented with a painless, left upper eyelid mass.

October 15, 2020
Original Investigation

Clinical Phenotype and Course of PDE6A-Associated Retinitis Pigmentosa Disease, Characterized in Preparation for a Gene Supplementation Trial

Abstract Full Text
JAMA Ophthalmol. Published online October 15, 2020. doi:10.1001/jamaophthalmol.2020.4206

In this cohort study, 57 patients with biallelic sequence variations in the PDE6A gene and retinitis pigmentosa were followed up to assess clinical features, genetic findings, and genotype-phenotype correlations of the disease.

Assessment of Pediatric Optic Neuritis Visual Acuity Outcomes at 6 Months

Abstract Full Text
has audio
JAMA Ophthalmol. Published online October 15, 2020. doi:10.1001/jamaophthalmol.2020.4231

This cohort study used data from pediatric ophthalmology and neuro-ophthalmology clinics in the United States and Canada to assess the 6-month visual acuity in pediatric patients with optic neuritis.

Lifetime Outcomes of Anti–Vascular Endothelial Growth Factor Treatment for Neovascular Age-Related Macular Degeneration

Abstract Full Text
JAMA Ophthalmol. Published online October 15, 2020. doi:10.1001/jamaophthalmol.2020.3989

This study evaluates visual acuity outcomes of anti–vascular endothelial growth factor treatment for neovascular age-related macular degeneration in both eyes for patients’ remaining life span.

Invited Commentary

Moving Towards PDE6A Gene Supplementation Therapy

Abstract Full Text
JAMA Ophthalmol. Published online October 15, 2020. doi:10.1001/jamaophthalmol.2020.4216

Pediatric Optic Neuritis—Building Foundations for a Randomized Clinical Trial

Abstract Full Text
JAMA Ophthalmol. Published online October 15, 2020. doi:10.1001/jamaophthalmol.2020.4250
JAMA Ophthalmology Clinical Challenge

Bilateral Atypical Eyelid Lesions in a 50-Year-Old Woman

Abstract Full Text
has active quiz
JAMA Ophthalmol. Published online October 15, 2020. doi:10.1001/jamaophthalmol.2020.2090

A 50-year-old woman is referred to the oculoplastic clinic for evaluation of bilateral vascular lesions of the eye, which can be seen beneath the palpable conjunctivae on the upper and lower eyelids. She denies changes in vision and pain but reports a sensation of pressure around the lesions, which is relieved in the prone position. She has a 25-year history of bulimia and purges almost daily. What would you do next?

October 8, 2020
Viewpoint

Strategies to Address Racial and Ethnic Disparities in Vision Care Research

Abstract Full Text
JAMA Ophthalmol. Published online October 8, 2020. doi:10.1001/jamaophthalmol.2020.3969

This Viewpoint discusses barriers to racial and ethnic minority representation in clinical research and provides recommendations to promote inclusion of these marginalized groups.

Original Investigation

Dual Sensory Impairment and Perceived Everyday Discrimination in the United States

Abstract Full Text
JAMA Ophthalmol. Published online October 8, 2020. doi:10.1001/jamaophthalmol.2020.3982

This study assesses the association of vision impairment, hearing impairment, and dual sensory impairments with everyday discrimination.

Brief Report

Severe Acute Respiratory Syndrome Coronavirus 2 Nucleocapsid Protein in the Ocular Tissues of a Patient Previously Infected With Coronavirus Disease 2019

Abstract Full Text
free access has active quiz
JAMA Ophthalmol. Published online October 8, 2020. doi:10.1001/jamaophthalmol.2020.3962

This case study compares a patient previously infected with coronavirus disease 2019 with a control participant in assessment of nucleocapsid protein antigens on the cells of the conjunctiva, iris, and trabecular meshwork.

JAMA Ophthalmology Clinical Challenge

A Woman With Bilateral Visual Field Defects

Abstract Full Text
has active quiz
JAMA Ophthalmol. Published online October 8, 2020. doi:10.1001/jamaophthalmol.2020.2056

A 52-year-old woman with no relevant medical history presents for evaluation of visual field defects. Her ocular history is notable for open-angle glaucoma in both eyes, diagnosed 3 months previously. What would you do next?

October 1, 2020
Original Investigation

Short-term Efficacy and Safety of Topical β-Blockers (Timolol Maleate Ophthalmic Solution, 0.5%) in Acute Migraine: A Randomized Crossover Trial

Abstract Full Text
JAMA Ophthalmol. Published online October 1, 2020. doi:10.1001/jamaophthalmol.2020.3676

This randomized crossover clinical trial compares the short-term efficacy of topical timolol ophthalmic solution with placebo for reducing pain scores after an acute migraine attack.

Association of Oxymetazoline Hydrochloride, 0.1%, Solution Administration With Visual Field in Acquired Ptosis: A Pooled Analysis of 2 Randomized Clinical Trials

Abstract Full Text
open access
JAMA Ophthalmol. Published online October 1, 2020. doi:10.1001/jamaophthalmol.2020.3812

This pooled analysis of 2 randomized clinical trials examines the efficacy and safety of oxymetazoline hydrochloride, 0.1%, ophthalmic solution in participants with acquired ptosis.

Safety and Efficacy of Low-Dose Atropine Eyedrops for the Treatment of Myopia Progression in Chinese Children: A Randomized Clinical Trial

Abstract Full Text
JAMA Ophthalmol. Published online October 1, 2020. doi:10.1001/jamaophthalmol.2020.3820

This randomized clinical trial evaluates the efficacy and safety of atropine, 0.01%, eyedrops on slowing myopia progression and axial elongation in Chinese children

Invited Commentary

Put a Drop of Timolol Into Each Eye and Call Me in the Morning

Abstract Full Text
JAMA Ophthalmol. Published online October 1, 2020. doi:10.1001/jamaophthalmol.2020.3837

Oxymetazoline for Ptosis

Abstract Full Text
JAMA Ophthalmol. Published online October 1, 2020. doi:10.1001/jamaophthalmol.2020.3833

Myopia Control With Low-Dose Atropine Eyedrops

Abstract Full Text
JAMA Ophthalmol. Published online October 1, 2020. doi:10.1001/jamaophthalmol.2020.3830
Research Letter

Outcomes of Adversarial Attacks on Deep Learning Models for Ophthalmology Imaging Domains

Abstract Full Text
JAMA Ophthalmol. Published online October 1, 2020. doi:10.1001/jamaophthalmol.2020.3442

This study investigates whether adversarial attacks can confuse deep learning systems based on imaging domains.

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