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Clinical Problem Solving: Pathology
Feb 2012

Pathology Quiz Case 2: Diagnosis

Author Affiliations


Arch Otolaryngol Head Neck Surg. 2012;138(2):208-209. doi:10.1001/archoto.2011.1245b

Diagnosis: Hyalinizing clear cell carcinoma

Hyalinizing clear cell carcinoma is a rare neoplasm of salivary gland origin that was first described as a distinct entity by Milchgrub et al1 in 1994. It accounts for fewer than 1% of salivary gland tumors.2,3 Salivary gland tumors as a whole account for fewer than 7% of all head and neck tumors.4 As of 2009, there were only 55 reported cases of hyalinizing clear cell carcinoma in the literature, to our knowledge.5 Hyalinizing clear cell carcinoma is now classified as clear cell carcinoma not otherwise specified by the World Health Organization,6 but the preference at our institution is hyalinizing clear cell carcinoma and that is the term that will be used throughout this discussion.