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Clinical Problem Solving: Pathology
Mar 2012

Pathology Quiz Case 2: Diagnosis

Arch Otolaryngol Head Neck Surg. 2012;138(3):318-319. doi:10.1001/archoto.2011.1238b

Sarcoidosis is a systemic granulomatous disease of unknown etiology that affects the worldwide population. While it occurs in all age groups, adults aged 30 to 49 years are most commonly affected.1 Approximately 10 to 40 adults per 100 000 are affected by sarcoidosis in the United States and Europe.2 It is much more rare in children. The yearly incidence increases from 0.06 per 100 000 children younger than 4 years to 1.02 per 100 000 children aged 14 to 15 years and continues to increase into early to middle adulthood.3 Although it is twice as prevalent in women as in men, this prevalence is not found in children: a Danish study revealed a male to female ratio of 1.09.3,4 Adult US patients of African American and Puerto Rican descent are more likely to develop sarcoidosis.2,5 Among children, the prevalence of sarcoidosis is greater in African Americans than in whites.2