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Clinical Problem Solving: Pathology
July 2011

Pathology Quiz Case 2: Diagnosis

Author Affiliations


Arch Otolaryngol Head Neck Surg. 2011;137(7):727-728. doi:10.1001/archoto.2011.102-b

Diagnosis: Wegener granulomatosis (WG) of the orbit

Wegener granulomatosis is a severe necrotizing granulomatous vasculitis that typically involves the arterial and venous circulation of both the respiratory tract and the kidneys. The classic triad of WG includes necrotizing granulomatous inflammation of the upper and lower respiratory tracts, systemic vasculitis of small arteries and veins, and focal glomerulonephritis. Wegener granulomatosis is noninfectious and is presumed to be an autoimmune entity. It exhibits a predilection for white individuals, with a specific predominance in those of Northern European ancestry. Males and females are equally affected, with a mean age of 50 years at diagnosis and an annual incidence of 10 per million.1