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Clinical Note
May 2012

More Than a Frog in the Throat: A Case Series and Review of Localized Laryngeal Amyloidosis

Author Affiliations

Author Affiliations: Department of Medicine (Drs Stevenson and Afghahi), Divisions of Cardiology (Dr Witteles), Otorhinolaryngology (Dr Damrose), Blood and Marrow Transplant (Dr Arai), Nephrology (Dr Lafayette), and Hematology (Drs Schrier and Liedtke) and Stanford Amyloid Center (Drs Witteles, Arai, Lafayette, Schrier, and Liedtke), Stanford University School of Medicine, Stanford, California.

Arch Otolaryngol Head Neck Surg. 2012;138(5):509-511. doi:10.1001/archoto.2012.423

Amyloidosis is a disease characterized by protein deposition in tissues and organs, most commonly the kidney, heart, liver, nervous system, and gastrointestinal tract.1 Extracellular fibrils form β-pleated sheets disrupting organ function. Over 20 different proteins have been observed in amyloidosis, but all forms are identified by Congo red stain and a green birefringence pattern under polarized light.