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Clinical Problem Solving: Radiology
May 2012

Radiology Quiz Case 1: Diagnosis

Arch Otolaryngol Head Neck Surg. 2012;138(5):516-517. doi:10.1001/archoto.2012.273b

Diagnosis: Non-Hodgkin lymphoma (NHL) (diffuse large B-cell type) of the frontal sinus

Lymphoma represents 3% to 5% of all malignant neoplasms, with NHL making up 60% of these cases. Primary NHL arising in the head and neck region accounts for 10% of all NHL cases. Primary extranodal lymphoma in the head and neck region presents in the nasal cavities, paranasal sinuses, and thyroid or salivary glands. Sites of involvement outside of the head and neck include the gastrointestinal tract, skin, and testis.1