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Clinical Note
Aug 2012

Inflammatory Pseudotumor of the Nasopharynx and Skull Base: Mimicking an Aggressive Neoplasm or Infection

Author Affiliations

Author Affiliations: Departments of Radiology (Drs Chwang, Narayan, and Rajan Jain), Neurosurgery (Dr Ruchika Jain), and Otolaryngology–Head and Neck Surgery (Drs Ghanem and Seidman), Henry Ford Health System, Detroit, Michigan; and Departments of Infectious Disease (Dr Ruchika Jain) and Pathology (Dr McHugh), University of Michigan Hospital, Ann Arbor.

Arch Otolaryngol Head Neck Surg. 2012;138(8):765-769. doi:10.1001/archoto.2012.1540

Inflammatory pseudotumor of the nasopharynx and skull base is a benign, idiopathic disease that is often mistaken for a neoplasm or infection owing to its aggressive behavior and clinical presentation. It can present as a progressively destructive mass and should be considered when repeated tissue biopsies reveal acute or chronic inflammation without evidence of malignant disease or infection. We present 4 cases of nasopharyngeal inflammatory pseudotumor with skull base invasion occurring in patients with diabetes mellitus (DM). These patients had repeated negative results from biopsies and cultures, and none had associated cervical lymphadenopathy despite having an aggressive destructive mass. We suggest that these findings, coupled with clinical suspicion, will be helpful in making the correct diagnosis of inflammatory pseudotumor. This is critical in the management of these patients to institute the correct treatment plan.