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Clinical Problem Solving: Pathology
Oct 2012

Pathology Quiz Case 1: Diagnosis

Author Affiliations


Arch Otolaryngol Head Neck Surg. 2012;138(10):978-979. doi:10.1001/archotol.138.10.978

Diagnosis: Multifocal granular cell tumor (GCT)

Granular cell tumor is an uncommon tumor that is reported to arise at nearly any site, commonly including the skin, vulva, breast, larynx, bronchus, and soft tissues, with more than 50% of cases involving the head and neck.1 Given the infrequency of this disease, epidemiologic data are lacking. The tumors appear to develop twice as frequently in females as in males and are 5-fold more common in those of African descent compared with whites. Patients with GCTs most commonly present between the ages of 20 and 50 years, with a mean age of 45 years at diagnosis.1