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Clinical Problem Solving: Pathology
Nov 2012

Pathology Quiz Case 1: Diagnosis

Author Affiliations


Arch Otolaryngol Head Neck Surg. 2012;138(11):1092. doi:10.1001/archotol.138.11.1092

Diagnosis: Intravascular papillary endothelial hyperplasia (IPEH)

Intravascular papillary endothelial hyperplasia is a proliferation of vascular endothelial cells that typically presents as a subcutaneous mass.1,2 In the upper aerodigestive tract, it may also present as a tender submucosal nodule or a bluish, raised mucosal lesion.3,4 The mass manifested in IPEH represents an exaggerated growth response by vascular endothelial cells as they respond to an inciting stimulus. It may occur in a normal blood vessel, in a vascular malformation, or as a response to local trauma. Intravascular papillary endothelial hyperplasia is generally believed to develop in the setting of recannalization after thrombosis.1