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Clinical Problem Solving: Pathology
January 2013

Pathology Quiz Case 2: Diagnosis

JAMA Otolaryngol Head Neck Surg. 2013;139(1):90. doi:10.1001/jamaoto.2013.1145b

Diagnosis: Laryngeal giant cell tumor (LGCT)

Giant cell tumors are benign neoplasms that account for 5% of all primary bone tumors. They are most often seen in the metaphysical-epiphysical area of the long bones, and the most frequent locations are the distal femur, proximal tibia, and distal radius. The peak incidence is between 20 and 40 years of age.1 Two percent of all GCTs are found in the head and neck region, particularly in the sphenoidal, ethmoidal, and temporal bones.2,3 The laryngeal form is very rare. The first case of a LGCT was reported in 1940, and, to our knowledge, only 31 histopathologically confirmed cases have been published in the literature.3,4

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