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Clinical Problem Solving: Pathology
February 2013

Pathology Quiz Case 2: Diagnosis

JAMA Otolaryngol Head Neck Surg. 2013;139(2):198. doi:10.1001/jamaoto.2013.1280b

Diagnosis: Extramedullary plasmacytoma (EMP)

Extramedullary plasmacytomas are monoclonal proliferations of plasma cells that are found in soft tissues. They represent only 1% of all head and neck tumors; however, more than 80% are located in the upper aerodigestive tract (UADT).1 Extramedullary plasmacytomas of the UADT are 3 times more common in males than in females.1 The sinonasal tract and nasopharynx are the most common subsites.1,2 To our knowledge, only 1 uvula plasmacytoma and fewer than 10 conjunctival plasmacytomas have been reported.3,4 Clinical symptoms of head and neck plasmacytomas vary depending on the location of the mass.