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Original Articles
June 1961

New Treatment of Paranasal Sinus Infections: Local Use of Pancreatic Dornase

Arch Otolaryngol. 1961;73(6):686-688. doi:10.1001/archotol.1961.00740020700013

The use of antibiotics has done a great deal to minimize complications and to reduce chronicity of infections. Unfortunately the effectiveness of antibiotics is limited and occasionally even antibiotic-resistant strains of bacteria will develop. Additional means to either enhance the antibiotic effect or reduce inflammation are most desirable. With this thought in mind, pancreatic dornase has been used in infections of the paranasal sinuses.

The preparation used in this study is Dornavac* which is a stabilized preparation of the enzyme deoxyribonuclease, derived from beef pancreas.6

Rationale of Therapy  According to Sherry,1 deoxyribonucleoprotein is an important constituent of puru- lent and inflammatory exudate and has been isolated in quantities ranging from 30%-70% of the total purulent sediment. It determines the character, viscosity, and amount of sediment in the exudate. Deoxyribonuclease is a pus-liquefying enzyme and is capable of degrading deoxyribonucleoprotein. The enzyme acts on extracellular fluids and disintegrating cells,

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