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July 1961

Antimicrobial Therapy

Arch Otolaryngol. 1961;74(1):1. doi:10.1001/archotol.1961.00740030004001

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In this issue of the Archives there appears an unusually fine Progress Report on Respiratory Infections and Antimicrobial Therapy. Prepared by Professor Saunders of Ohio State University, this is an extremely useful and practical summary of a rapidly changing and often confusing field due to the constant introduction of new agents, each accompanied by brightly colored advertising literature. Saunders agrees with the conclusions of a medical Progress Report in the New England Journal of Medicine for Nov. 10, 1960, that, although replaced in great part by antibiotics, sulfonamides, because of relative inexpensiveness, still occupy a small, but important place in the therapy of infectious diseases. Sulfadiazine, long the standard, has been largely replaced by sulfisoxazole, marketed as Gantrisin, because of the reduced toxicity of the latter.

Of the antibiotics, penicillin is still the "work-horse" with aqueous crystalline penicillin G, given intramuscularly or intravenously for rapid high serum concentrations. Procaine penicillin

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