The classical approach to problems of nasal pathology has been a study of the surface epithelium and its ciliary action, using the methods of Proetz.1 Since nasal polyposis truly represents grapelike herniations of mucosa filled with intracellular-extracellular-bound fluid, a hole punched in a polyp will not permit water to be squeezed out. As the water is released from its bound form, fluid may ooze out slowly. Therefore, it seems proper to turn our attention to the connective tissue which contains this fluid. This is a relatively new field of study, and, while much is known, in order to discuss the use of endocrines in controlling fluid production and retention by ground substance, we have to rely on educated guesses.
Connective tissue (Fig. 1) is composed of a ground substance matrix which embeds fibroblasts, histiocytes or primitive reticuloendothelial cells, lymphocytes, eosinophils, plasma cells, and mast cells. These are interspersed among
DOLOWITZ DA, DOUGHERTY TF. Nasal Polyposis. Arch Otolaryngol. 1961;74(2):171–177. doi:10.1001/archotol.1961.00740030176008
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