Cytological analyses of specimens obtained by scraping are widely employed in Italy nowadays in all the main specialized centers. The theoretical ideas for the clinical application of exfoliative cytology were advanced some 10 years ago by outstanding biologists and clinicians at an international symposium held in Milan.1 Particularly on account of the encouraging results obtained in the United States, we envisaged the possibility of employing the cytologic method on a wide scale, especially obtaining early diagnosis of neoplasms. Thus, a period of fairly broad experimentation was begun, based on the alignment of cytological research along with the regular histopathologic examinations. This enabled us to evaluate the suitability of the techniques employed and to determine which were the most frequent factors of technical or interpretive error. This period of preparation lasted about 10 years, and the results have recently been summed up in a symposium on "Cytodiagnosis in Oto-Rhino-Laryngology,"2
FERRERI G, CRIFO S. Cytological Diagnosis in Otorhinolaryngology: The Special Use of Lymph Nodal Puncture. Arch Otolaryngol. 1961;74(3):262–266. doi:10.1001/archotol.1961.00740030269006
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