Bruton,1 in 1952, in his paper on agammaglobulinemia first called attention to the fact that an abnormality in plasma proteins may be responsible for recurrent bacterial infections in a person. Since then, many authors2 have confirmed that in some cases of increased susceptibility to infections, deficiency of circulating plasma gamma globulin may play a decisive role. It has been established that immune bodies are mainly in the gamma globulin fraction, and gamma globulin formation is connected with resistance to infection. Nevertheless, there is no doubt now that the gamma globulin content, as determined by paper electrophoresis of the serum proteins, is not directly related to resistance to infections of the upper respiratory tract. Payne and Forsyth3 state that the increase in gamma globulin found in chronic infections is greater than could be accounted for by a rise in specific antibodies, as they form an infinitesimal part of
SZPUNAR J, RYBAKOWA M. Electrophoretic Serum Studies Studies of Children with Frequently Recurring Acute Tonsillitis. Arch Otolaryngol. 1961;74(3):267–271. doi:10.1001/archotol.1961.00740030274007
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