Oxyphil-cell adenoma (oncocytoma) is a benign tumor made up of acidophilic cells usually referred to as oncocytes. The tumor is always encapsulated, usually rounded or ovoid, but may appear irregular or coarsely nodular. There have been no instances of multiple separate or discrete tumors within the same gland. The tumors are homogeneous or lobulated and are soft and resilient. The cut surface may be brownish red, brownish pink, or pale pink. Cystic areas have been seen, but unlike those in papillary cystadenoma lymphomatosum, they are not an important characteristic. They are usually 3 to 4 cm. in diameter.
Microscopically, the cells are large, with pink cytoplasm and small, rounded nuclei. Cell outlines are distinct. The cytoplasm is finely granular under high power. Mitoses are usually absent, but, if they are present, they are few in number. The cells are characteristically arranged in columns or cords a few cells thick and
DIBBLE PA, SANFORD DM. Submaxillary Oncocytoma: Oxyphil-Cell Adenoma. Arch Otolaryngol. 1961;74(3):299–301. doi:10.1001/archotol.1961.00740030306011
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