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October 1961

Evaluation of a Topical Anesthetic —Dyclonine

Arch Otolaryngol. 1961;74(4):437-440. doi:10.1001/archotol.1961.00740030446014

Numerous reports relate the ill effects of commonly used topical anesthetic agents, although probably only a small percentage of such mishaps are reported.1 We thus felt it of value to appraise a relatively new compound, dyclonine,* which reportedly has a wide margin of safety. Clinically the drug has been used in the eye, mouth, bronchi, urethra, and on skin.2-7

Dyclonine is chemically different from any of the local anesthetics in use today.f The compound is a white crystalline powder soluble at a 2% concentration in water. Parenterally, in animals, the drug has been shown to have no autonomic action. There appeared to be no effect upon blood pressure, pulse, or central nervous system. This drug has been given to adult human beings by intravenous injections in doses from 200 to 500 mg. (40 to 100 cc. of 0.5%) over a 5-minute period. Nausea, dizziness, and vomiting were the