Anosmia occurring in healthy noses can be treated by vitamin A when the olfactory mucosa has been damaged. Vitamin A plays an important part in the physiology of olfaction in a comparable manner to its role in vision. High dosage vitamin A work was made possible with the synthesis of vitamin A by Isler and his colleagues in 1947 at Basle, and in 1951 the commercial preparations for oral and parenteral treatment were made available. The synthetic preparation was found to have the same activity as natural vitamin A. It was possible to give high dosage treatment in many conditions where degeneration or atrophy of epithelial tissues was a feature of their pathology. One of the earliest applications of this concept to the nose was the work of Stanbygård,2 who reported good results with treatment of ozena. He described how 6 patients regained their sense of smell as the
DUNCAN RB, BRIGGS M. Treatment of Uncomplicated Anosmia by Vitamin A. Arch Otolaryngol. 1962;75(2):116–124. doi:https://doi.org/10.1001/archotol.1962.00740040122008
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