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March 1962

Tobacco Habits in Oral and Upper Respiratory Carcinoma: A Review of 112 Cases

Arch Otolaryngol. 1962;75(3):245-247. doi:10.1001/archotol.1962.00740040253013

There is growing evidence of more than a casual relationship between smoking and bronchiogenic carcinoma. Since Hammond and Horn's monumental work was published in 1954, there has been increased interest in both lay groups and the medical profession regarding the carcinogenic properties of tobacco. The purpose of this paper is to show the tobacco habits of 112 patients with carcinoma of the oral and upper respiratory tract.

Wynder and Graham, in a series of 605 bronchiogenic carcinomas, found 96.5% of the patients were moderately heavy smokers. A total of 96.1% had smoked for over 20 years. Bronchiogenic carcinoma in the nonsmoker is a rarity; only 2% of their patients were nonsmokers. An immense amount of research has been done on the tobacco tars to find the agents responsible for the carcinogenic properties. The chemical 3,4- benzpyrene has been found to be a major offender, but other of the polycyclic hydrocarbons