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April 1962

Tracheal Prostheses: An Experimental Study in Dogs

Arch Otolaryngol. 1962;75(4):335-341. doi:10.1001/archotol.1962.00740040344006

Extensive experimental and clinical investigations which we recently reviewed1 failed to produce a satisfactory tracheal replacement. This study was made to evaluate tracheal prostheses composed of 3 different types of materials for "sleeve" reconstruction of the trachea and to observe regeneration of the respiratory epithelium. Furthermore, since continuous movement of the mucus in the tracheobronchial tree by the ciliated respiratory epithelium is of prime importance in cleansing the air passages, in vitro studies were made using graphite particles to evaluate the function of the regenerated epithelium.

Method  We selected 21 large dogs weighing 12 kg. or more because the diameter of their tracheas approximates that of man. The operations were performed under intravenous anesthesia, using pentobarbital (Nembutal), 30 mg. per kilogram.Group 1.—In eleven dogs, celiotomy was performed, and a portion of polyethylene plastic (Marlex) mesh, 6×6 cm., was sutured into the greater omentum. The Marlex mesh was removed

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