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General E.N.T.
April 1962

A Century of Cylindromas: Short Review and Report of 27 Adenoid Cystic Carcinomas Arising in the Upper Respiratory Passages

Arch Otolaryngol. 1962;75(4):364-376. doi:10.1001/archotol.1962.00740040373009

A cylindroma is a tumor usually easily recognized by biopsy and found most commonly in the salivary glands but occasionally arising in the lacrimal glands or from the mucous membranes of the mouth and respiratory tract. It is a malignant tumor that usually grows slowly but almost invariably leads to the death of the patient. When it arises in the upper respiratory passages, it metastasizes infrequently.

Microscopically, the tumor is composed of cytoplasm-poor cells arranged fairly compactly in more or less uniform sheets, strikingly punctured with large spaces that may contain hyaline material. Some degree of palisading of the cells around these spaces usually is present. The frequently used descriptive term of a "Swiss cheese" appearance is fairly apt.

It has been considered that those cylindromas arising from the upper portion of the respiratory passages have been inadequately examined in the light of a large clinical series; therefore, the present