The standard approach to the pituitary has for many years been via an anterior craniotomy, and the operation has in consequence been very largely in the hands of the neurosurgeons, While the operation was originally designed for the treatment of tumors of this gland, it has more recently become necessary to approach the normal gland in cases of inoperable carcinoma of the breast, particularly where secondary deposits are already in evidence.
Attempts have been made to destroy the gland in such cases by means of implanted radioactive material. While some successes have followed this method, the danger of damage to surrounding structures and of bone necrosis, together with the possibility of incomplete functional ablation, have caused it to fall out of favor. There has been, therefore, a swing toward surgical removal.
It has been suggested that some cases of advanced prostatic carcinoma might also benefit from hypophysectomy, but the evidence
MACBETH R, HALL M. Hypophysectomy as a Rhinological Procedure. Arch Otolaryngol. 1962;75(5):440–450. doi:10.1001/archotol.1962.00740040451012
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