A previous review of the advances in head and neck oncology1 emphasized the availability of 3 basic methods in the treatment and investigation of solid tumors. This included surgery, irradiation, and the use of chemotherapeutic agents.This report will outline more specifically the parameters of antitumoral agents in solid tumors of the head and neck. The overwhelming number of agents and the variations in opinion regarding the present status of chemotherapeutic drugs is indicative of the great endeavor now directed toward the investigation of this type of treatment in oncology.It is also a measurement of the caution which should be applied in the use of any chemical agent used for the necrosis and destruction of tumor tissue. This caution should be emphasized in the regional oncology of head and neck therapy, since the local tumor isolation of the chemical agent in this area is difficult, and the
NOVACK AJ. Head and Neck Oncology Advances for 1961: Present Status of Chemotherapy. Arch Otolaryngol. 1962;75(5):477–479. doi:10.1001/archotol.1962.00740040488018
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