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August 1962

Changes Produced by Kanamycin: Early Histologic Manifestations in the Inner Ears of Cats

Arch Otolaryngol. 1962;76(2):146-150. doi:10.1001/archotol.1962.00740050152008

Since the discovery of kanamycin in 1957,1 this antibiotic has been used clinically in conditions often treated with streptomycin or neomycin. Histopathologic evidence of ototoxicity2-6 similar to that seen from streptomycin and neomycin, and a lack of cochlear microphonic response and of Cr. VIII nerve action potentials2 have been reported in kanamycin toxicity. Comparison of cochlear microphonics between kanamycin-damaged and dihydrostreptomycin-damaged ears showed a much greater depression of response in patients demonstrating kanamycin in the serum 24 hours after the original injection. The histopathological changes reported were atrophy of the organ of Corti and a reduction of spiral ganglion cell population. Kanamycin B was found to be much more toxic than the original kanamycin.2 Typical concentrations of kanamycin used by previous investigators are as follows:

Hawkins: 50 mg. per kilogram for 75 days; 200 mg. per kilogram for 30, 50, 70, 75 days.

Owada: 250 mg.

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