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August 1962

Respiratory Infections and Antimicrobial Therapy

Arch Otolaryngol. 1962;76(2):188-190. doi:10.1001/archotol.1962.00740050194015

In 1907, Ehrlich introduced chemotherapy with his compound "606" and suggested the concept of magic bullets for specific bacteria. Fifty years later, there have been several thousand antibiotics discovered of which only about 20 are of clinical significance. None of the antibiotics are effective against viral infections, but new developments indicate that before long drugs may become available which will include viruses in their scope of effectiveness.

Penicillins  Sodium oxacillin (Prostaphlin, Bristol Laboratories) is a new oral penicillin with an antibacterial action similar to that of an earlier Bristol product, dimethoxyphenyl penicillin sodium (Staphcillin, methicillin). Both of these products are effective against penicillinase - producing staphylococci although neither product is as effective as penicillins V or G against nonresistant staphylococci. Like methicillin, the new product is essentially inactive against enterococci.The advantages of sodium oxacillin over dimethoxyphenyl penicillin sodium are, first, it is effective when given orally, and second, it exhibits

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