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Of interest to the otolaryngologist are research studies of the viral etiology of respiratory diseases, including the common cold. During the last decade, tissue culture techniques have resulted in the discovery of numerous new viruses. By means of serodiagnostic tests reported in the May 12, 1962 J.A.M.A., Hilleman and associates identified the specific virus in 40% of children with acute respiratory illness clinically diagnosed as probably of viral and not bacterial origin. Presumably the 60% of cases that did not show a rise in antibody titer to a known virus were due to viruses not yet identified.
Noteworthy was the multiplicity of causative viruses. Influenza virus A1, A2, B, and C accounted for 2.6% of cases; parainfluenza 1, 2, and 3 were found in 5.5% of cases; adenovirus caused 5.1% of cases; coryza virus caused 4.8%; while respiratory syncytial virus accounted for 17.2% of cases, nearly all occurring
SHAMBAUGH GE. Research into Viral Etiology of Colds. Arch Otolaryngol. 1962;76(3):199. doi:10.1001/archotol.1962.00740050207003
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