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September 1962

Laryngeal Granular-Cell Myoblastoma: Appearance with Pseudoepitheliomatous Hyperplasia

Arch Otolaryngol. 1962;76(3):239-244. doi:10.1001/archotol.1962.00740050247009

Granular-cell myoblastoma or Abrikossoff's tumor1,2 is relatively rare, especially when it occurs in the larynx. A review of the literature and the addition of a new case are presented to reemphasize the necessity for recognition and differentiation of the frequently accompanying pseudoepitheliomatous hyperplasia from squamous cell carcinoma.

This tumor is of sufficient rarity that the clinician is surprised when the pathological diagnosis of a granular-cell myoblastoma is rendered and is shocked when the pathologist suggests there may be an accompanying squamous cell carcinoma. Such was our experience, and this appeared to have happened to others.3-8 Only after the literature was consulted and the additional deeper sections of the histological preparations carefully re-examined did it become clear that the subepithelial "infiltrative appearing nests" of squamous cells were not carcinoma but rather pseudoepitheliomatous hyperplasia. This appearance in our case was the result of sectioning the specimen in such a

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