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General E.N.T.
September 1962

Hereditary Hemorrhagic Telangiectasia: Its Familial Pattern, Clinical Characteristics, and Surgical Treatment

Arch Otolaryngol. 1962;76(3):245-260. doi:10.1001/archotol.1962.00740050253010
Abstract

Sixty years ago, William Osler was observing members of 3 families with intractable nosebleeds. His patients were likely to bleed every day, sometimes profusely. As a result of nosebleeds they were chronically anemic and debilitated. They suffered from a condition that is now called hereditary hemorrhagic telangiectasia. In addition to epistaxis, there are other less well-known manifestations of this unusual but fascinating condition. Some are very important.

The purpose of this paper is first, to define the typical hereditary pattern; second, to describe the various clinical manifestations of hereditary hemorrhagic telangiectasia; third, to summarize my experiences with a newly described surgical method for control of nosebleeds; and fourth, to report and comment on the significant aspects of 40 new cases.

Historical  Hereditary hemorrhagic telangiectasia is sometimes called Osler's disease (as are several other conditions). More commonly the eponym Rendu-Osler-Weber is used. The first physician to report an example of the

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