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General E.N.T.
October 1962

Milestones in Research of Upper Respiratory Cilia

Arch Otolaryngol. 1962;76(4):346-351. doi:10.1001/archotol.1962.00740050356010

During the past few years a number of new facts have come to light regarding respiratory cilia. In spite of this increased knowledge, many gaps still remain to be closed.

Although the morphological structure of cilia in animals and humans has been partially clarified, the exciting cause of ciliary activity remains a mystery.

In view of recent findings it might be worth while to consider some of the highlights leading up to our present knowledge.

Previous to 300 years ago histology, as we understand it, was a closed book.

About the year 1660, a Dutchman named Antony Van Leeuwenhoek1 began grinding lenses and later developed the first compound microscope. In the same year Schneider2 described the nasal mucosa as the source of mucus. He stated that "Mucus may be squeezed out of the membrane of these regions even in the dead subject." Unfortunately he was unaware that

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