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Clinical Note
September 1998

Laryngeal Glycogenic Acanthosis Presenting as Leukoplakia

Author Affiliations

From the Department of Pathology and Laboratory Medicine, Allegheny University-Hahnemann, MCP♦ Hahnemann School of Medicine, Philadelphia, Pa.

Arch Otolaryngol Head Neck Surg. 1998;124(9):1029-1030. doi:10.1001/archotol.124.9.1029

We report a case of an incidental finding of glycogenic acanthosis of the larynx on autopsy in a 79-year-old man who died of myocardial infarction. The lesion was grossly recognized as a white plaque (leukoplakia) on the subglottic compartment of the left side of the larynx. Histological sections revealed thickened squamous mucosa positive for abundant glycogen on periodic acid–Schiff staining. No epithelial dysplasia was noted. The patient had a history of smoking. This case represents the first report of glycogenic acanthosis involving the larynx. This benign condition should be added to the vast differential diagnosis of leukoplakia in this anatomical location.

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