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Clinical Challenges
October 1998

Allergic Fungal Rhinosinusitis: Experience With Immunotherapy

Author Affiliations


Arch Otolaryngol Head Neck Surg. 1998;124(10):1178-1179. doi:10.1001/archotol.124.10.1178

IN AUGUST 1994, when we began a prospective study to investigate the effect of IT with specific fungal antigens in patients with AFRS, it was our initial intention to prove or disprove their harmful effect in this situation. We have been gratified to find that far from exacerbating the course of this generally relentless and recalcitrant disease, fungal IT appears to significantly alter the clinical course of these patients, sparing them from repeated surgery and the use of systemic corticosteroids. Although our experience now exceeds 4 years and more than 20 patients treated in this fashion, we continue to believe that what we do not know about AFRS far exceeds our certain knowledge of the subject.

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