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Clinical Note
December 1998

Hypopharyngeal Stenosis and Dysphagia Complicating Toxic Epidermal Necrolysis

Author Affiliations

Copyright 1998 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.1998

Arch Otolaryngol Head Neck Surg. 1998;124(12):1375-1376. doi:10.1001/archotol.124.12.1375

Toxic epidermal necrolysis (TEN) is a potentially fatal cutaneous reaction characterized by extensive epidermal necrosis, flaccid bullae, erosions, and mucous membrane involvement.1-3 Predisposing factors have yet to be identified; however, the incidence of TEN (number of cases per million population per year) was 2.7 times higher among elderly individuals than among young adults.4 Destruction of the epidermis results in the same life-threatening complications as extensive burns, with resulting erosions of mucous membranes.5 Toxic epidermal necrolysis produces poor wound healing; mucosal erosions may persist with significant morbidity.6 Hypopharyngeal stenosis has previously been identified as a complication of head and neck cancer, irradiation, chemical burns, or blunt trauma; to our knowledge, there have been no previous reports of TEN-induced hypopharyngeal stenosis.