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Resident's Page: Pathology
December 1998

Pathologic Quiz Case 2

Author Affiliations


Arch Otolaryngol Head Neck Surg. 1998;124(12):1397. doi:10.1001/archotol.124.12.1394

In 1987, the Histiocyte Society proposed that histiocytosis X, eosinophilic granuloma, Letterer-Siwe disease, Hand-Schüller-Christian syndrome, Hashimoto-Pritzker syndrome, self-healing histiocytosis, pure cutaneous histiocytosis, Langerhans cell granulomatosis, type II histiocytosis, and nonlipid reticuloendotheliosis should all be unified under the single diagnostic term LCH.1 Nonetheless, the appropriate nomenclature and grouping of these histologically compatible but clinically distinct lesions remain controversial. Some authors have proposed the term Langerhans cell granulomatosis to replace the term eosinophilic granuloma, as neither eosinophils or granulomas are necessary for the diagnosis. They argue that the term histiocytosis should be avoided, since Langerhans cells are a member of the dendritic cell family and are not true histiocytes.2