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Comment & Response
October 2015

Unusual Lacrimal Gland Tumor Epidemiology Explained

Author Affiliations
  • 1Department of Head and Neck Surgery, David Geffen School of Medicine, University of California–Los Angeles, Los Angeles
JAMA Otolaryngol Head Neck Surg. 2015;141(10):946-947. doi:10.1001/jamaoto.2015.2045

In Reply In our recent study,1 we surveyed the Surveillance, Epidemiology, and End Results Program (SEER) database to determine the prevalence and determinants of survival of malignant epithelial tumors of the lacrimal gland. In accordance with previous studies, we found that adenoid cystic carcinoma (ACC) is the predominant tumor found in the lacrimal gland. We also found a surprisingly high incidence of squamous cell carcinoma (SCC). There were many fewer cases of melanoma and transitional cell carcinoma (TCC) in the data that we analyzed. Previously, there have only been rare case reports of SCC within the lacrimal gland.2,3 Melanoma and TCC had also been reported in case reports.4,5

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