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May 2016

Utility of Diagnostic Molecular Markers for Evaluation of Indeterminate Thyroid Nodules

Author Affiliations
  • 1Division of Head and Neck Surgical Oncology, Department of Otolaryngology–Head and Neck Surgery, Nebraska Medicine, Omaha
  • 2Division of Head and Neck Surgery, Department of Otolaryngology, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania
JAMA Otolaryngol Head Neck Surg. 2016;142(5):421-422. doi:10.1001/jamaoto.2016.0142

An emerging philosophy of medicine in the 21st century is personalization of care. Critical factors in accomplishing this are to understand the genetic profile of the patient as well as the genetic profile and the clinicopathologic features of the disease affecting the patient. Progress has been made in defining the genetic alterations associated with differentiated thyroid cancers (DTCs). Unfortunately, the genetic profile of a DTC currently does not play a role in determining the extent of therapy for an individual patient with such a cancer.