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Comment & Response
August 2016

Gene Expression Classifier Testing and the Surgical Decision-Making Process for Patients With Thyroid Nodules

Author Affiliations
  • 1Veracyte, Inc, South San Francisco, California
JAMA Otolaryngol Head Neck Surg. 2016;142(8):806-807. doi:10.1001/jamaoto.2016.0200

To the Editor Noureldine and colleagues1 found that molecular testing with the Afirma gene expression classifier (GEC) did not have a significant effect on the surgical decision-making process for patients with thyroid nodules who presented for surgical consultation. However, this study1 evaluates the test’s performance using an approach that runs counter to the test’s intended use.

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