In Reply We appreciate the important comments and observations of Drs Portinari and Carcoforo regarding our article titled “The Role of SPECT/CT Lymphoscintigraphy and Radioguided Sentinel Lymph Node Biopsy in Managing Papillary Thyroid Cancer.”1
Our colleagues did perform a key pioneer study evaluating the presence of lymph node (LN) metastases and its correlation with patient age and some tumor characteristics (size, infiltration, and multifocality).2 However, there are differences among the former study and ours. In our work, we evaluated the likelihood of developing LN metastases with radioguided sentinel lymph node biopsy (rSLNB) in relation to multiple patient, laboratory, and tumor characteristics. Therefore, we analyzed also sex, stimulated thyroglobulin levels, variant types, lymphatic invasion, vascular invasion, and surgical margins. Only the size of the primary tumor presented a significant association between LN metastases.
Cabrera RN, Mattiolli A, Etchebehere ECSC. Lymph Node Biopsy in Patients With Papillary Thyroid Cancer—Reply. JAMA Otolaryngol Head Neck Surg. 2017;143(4):429–430. doi:10.1001/jamaoto.2016.3659
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