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The local inflammatory damage and/or immunodeficiency associated with chronic rhinosinusitis (CRS) may increase the risk for head and neck cancer (HNC), but the relationship is not well studied. Beachler and Engels conducted a case-cohort analysis of US individuals aged 65 years and older using the Surveillance, Epidemiology, and End Results (SEER) database to determine the incidence of HNC in individuals with and without CRS. They found that CRS was associated with an increased risk of HNC, but the increased risk was limited in large part to within 1 year of CRS diagnosis, suggesting that the association may be a result of surveillance or detection bias. Suh et al provide an Invited Comentary.
Highlights. JAMA Otolaryngol Head Neck Surg. 2017;143(1):3. doi:10.1001/jamaoto.2016.1345
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