What are the clinical practice changes following the implementation of the updated 2015 American Thyroid Association guidelines on the extent of thyroidectomy procedures?
In this cohort study of 169 patients with pathologically proved, well-differentiated thyroid carcinoma, patients who underwent surgery between 2013 and 2014 were compared with patients who underwent surgery during 2016 following implementation of the new 2015 American Thyroid Association guidelines. Rates of up-front total thyroidectomy significantly decreased from 61% to 31%, and the rate of completion thyroidectomy significantly decreased from 74% to 20% following the implementation of the new guidelines.
The extent of thyroidectomy was reduced considerably following the 2015 American Thyroid Association guidelines, and only 1 of 5 patients who undergo thyroid lobectomy will require a completion procedure according to the new criteria.
The recommended extent of surgery for well-differentiated thyroid carcinoma has been modified considerably in the updated 2015 American Thyroid Association guidelines published in January 2016. To date, the changes in clinical practice after publication of these new guidelines have not been demonstrated.
The aim of this study was to evaluate clinical practice changes associated with implementation of the updated guidelines on the surgical procedure rates of total thyroidectomy, thyroid lobectomy, and completion thyroidectomy at a single tertiary medical center.
Design, Setting, and Participants
This is a retrospective cohort study of 169 patients at the Hadassah–Hebrew University Medical Center, Jerusalem, Israel. Patients with pathologically proved, well-differentiated thyroid carcinoma who underwent surgery between January 1, 2013, and December 31, 2014, were compared with patients who underwent surgery from January 1 to December 31, 2016. A total of 434 thyroidectomy procedures were performed during the study period, and 251 had pathologically proved, well-differentiated thyroid carcinoma. Patients with tumors larger than 4 cm, involved lymph nodes, or bilateral nodules were excluded.
Main Outcomes and Measures
Primary outcomes were the rate of up-front total thyroidectomy vs lobectomy and the rates of completion thyroidectomy before and after the implementation of the new guidelines.
Of the 169 patients in the final analysis, 118 (69.8%) were included from 2013 to 2014 and 51 (30.2%) in 2016. The mean (SD) age for the entire cohort was 44 (13.8) years, and 129 (76.3%) were women. Up-front total thyroidectomy was performed in 72 of 118 patients (61.0%) prior to the 2015 American Thyroid Association guidelines and 16 of 51 (31.4%) following their implementation (odds ratio, 0.29; 95% CI, 0.14-0.59). The rate of completion thyroidectomy also significantly decreased between these periods (73.9% vs 20.0%; odds ratio, 0.09; 95% CI, 0.04-0.19).
Conclusions and Relevance
The updated 2015 American Thyroid Association guidelines implementation was associated with a significant decrease in the rates of both up-front total thyroidectomy and completion thyroidectomy. According to these findings, only 1 of 5 patients who undergoes thyroid lobectomy will require a completion procedure.
Hirshoren N, Kaganov K, Weinberger JM, et al. Thyroidectomy Practice After Implementation of the 2015 American Thyroid Association Guidelines on Surgical Options for Patients With Well-Differentiated Thyroid Carcinoma. JAMA Otolaryngol Head Neck Surg. Published online March 29, 2018. doi:10.1001/jamaoto.2018.0042
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