Clinicians often rely on use of ototopical antibiotic drops to treat clogged tympanostomy tubes despite their lack of efficacy. Chan et al investigated the safety of dornase alfa, a recombinant enzyme that cleaves DNA, to treat clogged tympanostomy tubes in an animal study of 21 chinchillas, and subsequently evaluated its efficacy in a randomized clinical trial of 40 children. The authors found that dornase alfa was nonototoxic in the chinchilla model. In the clinical trial, dornase alfa was not significantly more effective than the ofloxacin treatment used as a control.
Highlights. JAMA Otolaryngol Head Neck Surg. 2018;144(9):767. doi:10.1001/jamaoto.2017.1971
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