Systematic reviews are the highest level of evidence in otolaryngology clinical practice guidelines.1 However, they generally present only formally published data, which may lead to an inherent problem caused by publication bias, that is, a strong bias to publish only studies that show significant results.2,3 This bias can be mitigated through both the search methods selected and the statistical methods used.
Ross A, Cooper C, Gray H, Umberham B, Vassar M. Assessment of Publication Bias and Systematic Review Findings in Top-Ranked Otolaryngology Journals. JAMA Otolaryngol Head Neck Surg. Published online December 06, 2018. doi:10.1001/jamaoto.2018.3301
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