The oculocardiac reflex is a well-known physiologic phenomenon in which traction to the extraocular muscles or compression of the globe causes a depression in heart rate—the afferent limb of the reflex is the trigeminal nerve and the efferent limb consists of the vagal nerve and parasympathetic nervous system. A less commonly reported phenomenon is the oculorespiratory reflex.1 We present a case of suspected oculorespiratory reflex affecting intraoperative ventilation in a patient undergoing repair of an orbital floor fracture.