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Research Letter
April 25, 2019

Use of Clinical Trial Registries in Otolaryngology Systematic Reviews

Author Affiliations
  • 1Center for Health Sciences, Department of Psychiatry and Behavioral Sciences, Oklahoma State University, Tulsa
JAMA Otolaryngol Head Neck Surg. Published online April 25, 2019. doi:10.1001/jamaoto.2019.0521

Systematic reviews are foundational to evidence-based patient care, yet these reviews are criticized for including only statistically significant findings to estimate summary effects, which may lead to publication bias.1,2 The exclusion of nonsignificant and/or unpublished results can lead to an overrepresentation of an intervention’s actual effect and potentially imprecise clinical decision making.3,4 Although many methods exist to minimize publication bias in systematic reviews, the use of clinical trial registries (CTRs) is particularly encouraging.