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Comment & Response
June 6, 2019

Association Between Red Blood Cell Width and Modified Frailty Index—Reply

Author Affiliations
  • 1Department of Otolaryngology–Head and Neck Surgery, Vanderbilt University Medical Center, Nashville, Tennessee
  • 2Surgical Outcomes Center for Kids, Vanderbilt University Medical Center, Nashville, Tennessee
JAMA Otolaryngol Head Neck Surg. 2019;145(8):768. doi:10.1001/jamaoto.2019.0920

In Reply We thank Dr Lin for the thoughtful review of the utility of the Modified Frailty Index (mFI) to stratify the frailty of surgical patients, as well as for highlighting the correlation between the mFI and red blood cell distribution width (RDW) in patients with coronary artery disease.1 With that correlation in mind, the proposal that the 2 markers may share a common pathophysiology in adults undergoing airway reconstruction is an interesting one. Accordingly, we reanalyzed the data set. Logistic regression using Newton-Raphson algorithm between mFI and RDW demonstrated low correlation (0.37). Multicolinearity analysis between mFI, RDW, and prosthesis-free breathing failed to demonstrate correlation.

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