In Reply We thank Dr Lin for the thoughtful review of the utility of the Modified Frailty Index (mFI) to stratify the frailty of surgical patients, as well as for highlighting the correlation between the mFI and red blood cell distribution width (RDW) in patients with coronary artery disease.1 With that correlation in mind, the proposal that the 2 markers may share a common pathophysiology in adults undergoing airway reconstruction is an interesting one. Accordingly, we reanalyzed the data set. Logistic regression using Newton-Raphson algorithm between mFI and RDW demonstrated low correlation (0.37). Multicolinearity analysis between mFI, RDW, and prosthesis-free breathing failed to demonstrate correlation.
Wootten CT. Association Between Red Blood Cell Width and Modified Frailty Index—Reply. JAMA Otolaryngol Head Neck Surg. 2019;145(8):768. doi:10.1001/jamaoto.2019.0920
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