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July 18, 2019

Plasmablastic Lymphoma of the Nasal Septum

Author Affiliations
  • 1Department of Otolaryngology–Head & Neck Surgery, Walter Reed National Military Medical Center, Bethesda, Maryland
  • 2Department of Otolaryngology–Head & Neck Surgery, Kaiser Permanente–Mid Atlantic Permanente Group, Falls Church, Virginia
  • 3Department of Pathology, Kaiser Permanente Mid Atlantic, Regional Laboratory, Rockville, Maryland
JAMA Otolaryngol Head Neck Surg. 2019;145(9):868-869. doi:10.1001/jamaoto.2019.1719

Plasmablastic lymphoma (PBL) is an aggressive form of non-Hodgkin lymphoma associated with human immunodeficiency virus (HIV) and Epstein-Barr virus (EBV) infections.1,2 Prognosis is poor, with most patients succumbing to fulminant metastatic disease within the first year of diagnosis. The oral cavity is the most commonly reported location of PBL followed by the gastrointestinal tract, lymph nodes, and skin.3 We present a case of PBL presenting as a solitary nasal septal mass.